Results 51 to 60 of about 176,129 (184)
The role of Qa-2, the functional homolog of HLA-G, in a Behcet's disease-like mouse model induced by the herpes virus simplex [PDF]
, 2010 BACKGROUND: It has been suggested that the HLA-G molecule is a genetic risk factor for Behcet's disease (BD). In this study, we evaluated the level of Qa-2, a murine nonclassical class I MHC molecule and possible functional homolog of HLA-G, to determine
Meeyoung Lee +6 more
core +1 more source
Expression of HLA-G in human cornea, an immune-privileged tissue. [PDF]
, 2003 Human leukocyte antigen (HLA)-G retains the capacity to modulate immune responses, favoring the establishment of tolerance in solid-tissue allotransplants.
Carosella, Edgardo D +4 more
core +2 more sources
HLA-G Dimers in the Prolongation of Kidney Allograft Survival
Journal of Immunology Research, 2014 Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with ...
Maureen Ezeakile +7 more
doaj +1 more source
Frontiers in Immunology, 2015 Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas HLA-G expression is expected to
Fabrício César Dias +4 more
doaj +1 more source
HLA-G in Allergy: Does It Play an Immunoregulatory Role?
Frontiers in Immunology, 2022 Allergy is an inflammatory process determined by a cascade of immune events characterized by T-helper 2 lymphocytes polarization leading to interleukin-4 upregulation, IgE secretion, and mast cell and eosinophil activation.
Simone Negrini +3 more
doaj +1 more source
Non-classical immunology. Meeting Report [PDF]
, 2001 This large annual immunology meeting covered a wide range of subjects from biochemical protein characterizations to cell biology and the study of complex disease pathologies.
Allen, RL
core +1 more source
Some Basic Aspects of HLA-G Biology
Journal of Immunology Research, 2014 Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble ...
Estibaliz Alegre +5 more
doaj +1 more source
Lymphocyte cell-cycle inhibition by HLA-G is mediated by phosphatase SHP-2 and acts on the mTOR pathway. [PDF]
PLoS ONE, 2011 Human leukocyte antigen G (HLA-G) is involved in regulating T-cell responses through its interaction with inhibitory receptors belonging to the immunoglobulin-like transcript family (ILT).
Farah Ketroussi +5 more
doaj +1 more source
Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
core +1 more source
Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis [PDF]
, 2018 Background. Ankylosing Spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of HLA-B27 alleles. HLA-E are non-classical MHC class I molecules that specifically interact with the natural killer receptors NKG2A ...
Angioni, Mm +12 more
core +1 more source