Results 51 to 60 of about 12,878,485 (338)

HLA-G remains a mystery

Trends in Immunology, 2001
In this brief summary, we argue that many widely held beliefs about HLA-G are questionable. Recent research has led to a re-evaluation of many of the characteristics that were thought to make HLA-G unusual among the MHC class I molecules. First, contrary to reports suggesting that the gene encoding HLA-G exhibits marked polymorphism in some human ...
Bainbridge, D, Ellis, S, Le Bouteiller, P, Sargent, I   +3 more
openaire   +3 more sources

Heterogeneity of HLA-G Expression in Cancers: Facing the Challenges

Frontiers in Immunology, 2018
Phenotypic heterogeneity has been observed in most malignancies, which represents a considerable challenge for tumor therapy. In recent decades, the biological function and clinical significance of the human leukocyte antigen (HLA)-G have been ...
A. Lin, Wei-Hua Yan
semanticscholar   +1 more source

Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis

Immunobiology
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen
Ines Zemni, Daria Bortolotti, Sabrine Dhouioui, Sana Baroudi, Malek Ferjani, Inès Nasri, Yosr Zenzri, Md Ataur Rahman, Abdel Halim Harrath, Roberta Rizzo, Nadia Boujelbene, Inès Zidi   +11 more
doaj   +1 more source

HLA-G Haplotypes Are Differentially Associated with Asthmatic Features

Frontiers in Immunology, 2018
Human leukocyte antigen (HLA)-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells, and natural killer cells to influence immune responses.
Camille Ribeyre, Federico Carlini, Céline René, Céline René, François Jordier, François Jordier, Christophe Picard, Christophe Picard, Jacques Chiaroni, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Grégory Marin, Nicolas Molinari, Nicolas Molinari, Pascal Chanez, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro, Julie Di Cristofaro   +21 more
doaj   +1 more source

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity [PDF]

, 2014
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function of class I non-classical genes.
Audrey eSabbagh, Audrey eSabbagh, Celso T Mendes-Junior, Eduardo A Donadi, Erick C Castelli, Iane O.P. Porto, Jaqueline eRamalho, Leandro P Felício, Thálitta H.A. Lima   +8 more
core   +2 more sources

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

Journal of Immunology Research, 2017
The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor ...
Marica Garziera, Lucia Scarabel, Giuseppe Toffoli   +2 more
doaj   +1 more source

HLA-G: facts and fictions

Asian Pacific Journal of Cancer Biology, 2018
Human leukocyte antigen (HLA)-G is a nonclassical MHC class I molecule with modulatory effects on NK and T cells. Unlike classical HLA class I molecules, HLA-G has seven isoforms, three of which are soluble. Soluble HLA-G molecules are reportedly able to
Shirin Farjadian
doaj   +3 more sources

HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia

Journal of Immunology Research, 2014
Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. The clinical relevance of HLA-G in several malignancies has been reported.
Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori   +5 more
doaj   +1 more source

The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?

International Journal of Molecular Sciences, 2020
Human leukocyte antigen G (HLA-G) mediates maternal-fetal immune tolerance. It is also considered an immune checkpoint in cancer since it may mediate immune evasion and thus promote tumor growth. HLA-G is, therefore, a potential target for immunotherapy.
Jiji V D Attia, Charlotte E Dessens, R. van de Water, R. Houvast, P. Kuppen, D. Krijgsman   +5 more
semanticscholar   +1 more source

HLA-G UTR haplotype conservation in the Malian population: association with soluble HLA-G. [PDF]

PLoS ONE, 2013
The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5'URR and 3'UTR ...
Federico Carlini, Karim Traore, Nissem Cherouat, Pierre Roubertoux, Stéphane Buhler, Martì Cortey, Sophie Simon, Ogobara Doumbo, Jacques Chiaroni, Christophe Picard, Julie Di Cristofaro   +10 more
doaj   +1 more source