Results 91 to 100 of about 313,560 (297)

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, EarlyView.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Comparative analyses of the results of HLA genes typing by NGS method using different platforms

Медицинская иммунология
Next generation sequencing (NGS) allows high-resolution and allelic HLA-typing. The most common platform is MiSeq (Illumina, USA). Currently, the maintenance of this device is difficult, which has necessitated the search for analogues that are not ...
I. E. Pavlova, E. V. Kuzmich, E. G. Khamaganova, D. V. Rudik, E. P. Kuzminova, A. R. Abdrakhimova   +5 more
doaj   +1 more source

An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis

Advanced Science, EarlyView.
In this study, the expression and function of LCN2 in GC is aimed to investigate and elucidate the mechanisms by which the LCN2‐dependent positive‐feedback loop between GC cells and TAMs drives lymphangiogenesis and lymphatic metastasis. These findings suggest that LCN2 may serve as a potential prognostic biomarker and therapeutic target in GC ...
Zhixin Huang, Ying Li, Yan Qian, Linying Ye, Tianhao Zhang, Yang Cheng, Jialin Wu, Peng Duan, Tiantian Zhang, Zihan Yu, Zeyu Zhao, Risheng Zhao, Zhi Liang, Ertao Zhai, Shirong Cai, Jianhui Chen   +15 more
wiley   +1 more source

Clinical significance of class II HLA genes (DRB1, DQA1 and DQB1) in tick-born encephalitis

Медицинская иммунология
Tick-borne encephalitis is a natural endemic disease which is widely spread in Russia. The purpose of the study was to determine clinical significance of HLA class II genes in tick-borne encephalitis.
O. N. Lyubeznova, A. L. Bondarenko
doaj   +1 more source

HLA and H-2 [PDF]

, 1979
Rolf M. Zinkernagel
openalex   +1 more source

Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury

Advanced Science, EarlyView.
A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton, Victoria Marsh Durban, Riccardo Barrile, Michael A. Helmrath, Takanori Takebe, Adrian Roth, Magdalena Kasendra   +11 more
wiley   +1 more source

Distribution of Major Histocompatibility Complex Alleles in Cohorts of Patients with Different Levels of Post-­Vaccination Antibodies against Hepatitis B

Эпидемиология и вакцинопрофилактика
Relevance. It is known that the immune response to the administration of immunobiological drugs is variable and depends on the individual characteristics of the organism.
N. V. Vlasenko, M. D. Chanyshev, A. V. Peresadina, A. A. Grishaeva, T. A. Semenenko, A. V. Snitsar, L. V. Lyalina, S. N. Kuzin, K. F. Khafizov, V. G. Akimkin   +9 more
doaj   +1 more source

Aletos HLA DQ alfa maternos, pérdida recurrente del embarazo y síndrome de anticuerpos antifosfolípidos

, 1969
A. E. Beer, Joanne Y.H. Kwak, J Cubillos, P. Sandoval, Julio Mendoza, F. Espinel   +5 more
openalex   +2 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Immunological and Immunogenetic Aspects of Vaccination against Measles

Эпидемиология и вакцинопрофилактика
Relevance. Measles meets the criteria for a disease that can be eradicated. However, it has not yet been possible to achieve sustainable elimination of this infection, and the duration of post-vaccination measles immunity is becoming an important issue ...
V. I. Fomichev, S. M. Kharit, A. A. Vilnits   +2 more
doaj   +1 more source