Results 111 to 120 of about 589,195 (286)

Clinical, bio­chemical and genetic characteristics of familial forms of type 1 diabetes

Сахарный диабет
BACKGROUND: Familial clustering of type 1 diabetes (T1D) highlights the importance of genetic and environmental factors in the pathophysiology of diabetes mellitus (DM).
I. M. Zufarova, D. N. Laptev, I. R. Minniahmetov, R. I. Khusainova, S. V. Popov, E. V. Titovich, I. A. Eremina, V. A. Peterkova   +7 more
doaj   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Estudio de HLA en Amerindios Colombianos

Iatreia, 2013
INTRODUCCIÓN: Colombia es un país al norte de Suramérica y debido a esta posición privilegiada fue la entrada para la colonización española desde el siglo XVI al continente.
Carlos Parga Lozano, Paola Chamorro Alfaro, Leyla Montes Pacheco, Angie Laserna Moreno, Kelly García Herrera   +4 more
doaj  

Transfusion-associated graft-versus-host disease (TA-GVHD) and graft-versus-host disease (GVHD): Pathophysiology and management (contrasted and compared)

Hematology/Oncology and Stem Cell Therapy
Transfusion of blood products is a common lifesaving medical procedure in clinical practice. However, it poses the risk of potential adverse reactions for the recipient.
Serena Valsami, Georgios Dryllis, Kassiani Papanastasi, Styliani Kokoris, Anastasios Kriebardis, Konstantinos Nikitiadis, Konstantinos Konstantopoulos, Marianna Politou   +7 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Cold-stored platelets：activity changes, preservation techniques and clinical application progress

Zhongguo shuxue zazhi
Research has confirmed that compared to traditional room temperature-stored platelets [RTP, (22±2) ℃], cold-stored platelets (CSP, 1-6℃) extend the stored time by inhibiting bacterial proliferation, representing an important strategy to break through the
WEN Yujie, JIA Yanjun
doaj   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of TCE‐secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Frequency of the Main Human Leukocyte Antigen A, B, DR, and DQ Loci Known to Be Associated with the Clearance or Persistence of Hepatitis C Virus Infection in a Healthy Population from the Southern Region of Morocco: A Preliminary Study

Diseases
Hepatitis C Virus (HCV) infection represents a significant global health challenge, with its natural course largely influenced by the host’s immune response. Human Leukocyte Antigen (HLA) molecules, particularly HLA class I and II, play a crucial role in
Safa Machraoui, Khaoula Errafii, Ider Oujamaa, Moulay Yassine Belghali, Abdelmalek Hakmaoui, Saad Lamjadli, Fatima Ezzohra Eddehbi, Ikram Brahim, Yasmine Haida, Brahim Admou   +9 more
doaj   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Иммуногенетический профиль (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1) популяции русских Челябинской области

Гематология и трансфузиология, 2015
Ре зюме. Проведено иммуногенетическое типирование 591 донора ГБУЗ Челябинская областная станция переливания крови, идентифицирующих себя русскими, по 5 генам HLA-А, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 на базовом разрешении. Был использован метод полимеразной цепной реакции с сиквенс-специфическими праймерами (SSP-PCR) со стандартными наборами (“Protrans”,
openaire   +1 more source