Results 121 to 130 of about 589,195 (286)

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Towards an HLA Run-time Infrastructure with Hard Real-time Capabilities [PDF]

, 2010
Our work takes place in the context of the HLA standard and its application in real-time systems context. The HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems.
Adelantado, Martin, Chaudron, Jean-Baptiste, Siron, Pierre   +2 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Staphylococcus argenteus and Staphylococcus schweitzeri are cytotoxic to human cells in vitro due to high expression of alpha-hemolysin Hla

Virulence, 2019
Staphylococcus argenteus and Staphylococcus schweitzeri are newly identified species of the S. aureus-related complex. S. argenteus, as occurring globally and showing significant prevalence and comparable infection and morbidity rates compared to S ...
Cecilia Johansson, Hilpi Rautelin, René Kaden   +2 more
doaj   +1 more source

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

Advanced Science, EarlyView.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng, Jiajing Xie, Luqi Wang, Hailong Xie, Tong Zhi, Yujia Guo, Bofeng Zhu, Dong Wang, Yu Chen   +8 more
wiley   +1 more source

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

, 2018
Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely ...
A Han, A Kosmrlj, A Leslie, A Leslie, A Lissina, A Sette, AJ Frater, AJ Leslie, B. Walker, BE Willcox, C Geldmacher, C Geldmacher, CF Thobakgale, CK Koofhethile, D Bernal-Estevez, F Bihl, F Pereyra, G Anmole, GM Gillespie, H Chen, H Crawford, HA Prentice, HN Kloverpris, HN Kloverpris, HN Kloverpris, J Nikolich-Zugich, J Sidney, JE Sunshine, JJ Miles, JJ Miles, JK Wright, JK Wright, JM Carlson, JR Almeida, K Ladell, KH Lee, KM Armstrong, M Bunce, MA Brockman, MA Brockman, MC Iglesias, MR Henn, N Goonetilleke, OO Yang, OY Borbulevych, P Borrow, P Kiepiela, P Kiepiela, PJ Goulder, PJ Goulder, PJ Goulder, R Draenert, R Suzuki, RA Kaslow, RA Koup, RS Ntale, SA Migueles, SA Migueles, SC Threlkeld, SG Deeks, SJ Davis, SJ Turner, SJ Turner, T Akahoshi, T Ueno, TM Allen, X Gao, Y Kawashima, Y Moosa   +68 more
core   +2 more sources

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Neoantigen cancer vaccines: a new star on the horizon

Cancer Biology & Medicine
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient’s own immune system and eliminate cancer cells.
Xiaoling Li, Jian You, Liping Hong, Weijiang Liu, Peng Guo, Xishan Hao   +5 more
doaj   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides. [PDF]

, 2020
Risk of the development of multiple sclerosis (MS) is known to be increased in individuals bearing distinct class II human leukocyte antigen (HLA) variants, whereas some of them may have a protective effect.
Bashinskaya, Vitalina, Baulina, Natalia, Belogurov, Alexey, Boyko, Alexey, Favorov, Alexander, Favorova, Olga, Filimonova, Ioanna, Gabibov, Alexander, Khaitov, Musa, Kiselev, Ivan, Kulakova, Olga, Mamedov, Azad, Poroshina, Alina, Shilovskiy, Igor, Smirnov, Ivan, Sykulev, Yuri, Vlassov, Valentin, Vorobyeva, Nadezhda, Zakharova, Maria, Ziganshin, Rustam   +19 more
core   +1 more source