Results 121 to 130 of about 676,827 (333)

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

, 2018
Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely ...
A Han, A Kosmrlj, A Leslie, A Leslie, A Lissina, A Sette, AJ Frater, AJ Leslie, B. Walker, BE Willcox, C Geldmacher, C Geldmacher, CF Thobakgale, CK Koofhethile, D Bernal-Estevez, F Bihl, F Pereyra, G Anmole, GM Gillespie, H Chen, H Crawford, HA Prentice, HN Kloverpris, HN Kloverpris, HN Kloverpris, J Nikolich-Zugich, J Sidney, JE Sunshine, JJ Miles, JJ Miles, JK Wright, JK Wright, JM Carlson, JR Almeida, K Ladell, KH Lee, KM Armstrong, M Bunce, MA Brockman, MA Brockman, MC Iglesias, MR Henn, N Goonetilleke, OO Yang, OY Borbulevych, P Borrow, P Kiepiela, P Kiepiela, PJ Goulder, PJ Goulder, PJ Goulder, R Draenert, R Suzuki, RA Kaslow, RA Koup, RS Ntale, SA Migueles, SA Migueles, SC Threlkeld, SG Deeks, SJ Davis, SJ Turner, SJ Turner, T Akahoshi, T Ueno, TM Allen, X Gao, Y Kawashima, Y Moosa   +68 more
core   +2 more sources

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Иммуногенетический профиль (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1) популяции русских Челябинской области

Гематология и трансфузиология, 2015
Ре зюме. Проведено иммуногенетическое типирование 591 донора ГБУЗ Челябинская областная станция переливания крови, идентифицирующих себя русскими, по 5 генам HLA-А, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 на базовом разрешении. Был использован метод полимеразной цепной реакции с сиквенс-специфическими праймерами (SSP-PCR) со стандартными наборами (“Protrans”,
openaire   +1 more source

HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion [PDF]

, 2013
Sanja Stevanović, Cornelis A.M. van Bergen, Simone A.P. van Luxemburg-Heijs, Boris van der Zouwen, Ekaterina S. Jordanova, Alwine B. Kruisselbrink, Marian van de Meent, Jessica C. Harskamp, Frans H.J. Claas, Erik W.A. Marijt, Jaap Jan Zwaginga, Constantijn J.M. Halkes, Inge Jedema, Marieke Griffioen, J.H. Frederik Falkenburg   +14 more
openalex   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Selección de variantes farmacogenómicas y metodología para su uso en farmacia comunitaria

Farmacéuticos Comunitarios
Los organismos reguladores, como la Food and Drug Administration (FDA) y la European Medicines Agency (EMA), reconocen la farmacogenética como una herramienta clave en sus guías farmacológicas para el asesoramiento farmacéutico.
Almudena Montero-Gómez, Antonio Sánchez Pozo   +1 more
doaj   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

Estudio de una población barranquillera basada en los alelos DRB1 y DQB1 comparada con otras poblaciones suramericanas

Revista Alergia México, 2018
Antecedentes: Todavía se desconoce el origen del poblamiento americano, pero con el tiempo se han desarrollado diversas teorías al respecto. Colombia fue un importante vínculo entre los hemisferios Norte y el Sur del continente americano.
Carlos Hernando-Parga
doaj  

Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides. [PDF]

, 2020
Risk of the development of multiple sclerosis (MS) is known to be increased in individuals bearing distinct class II human leukocyte antigen (HLA) variants, whereas some of them may have a protective effect.
Bashinskaya, Vitalina, Baulina, Natalia, Belogurov, Alexey, Boyko, Alexey, Favorov, Alexander, Favorova, Olga, Filimonova, Ioanna, Gabibov, Alexander, Khaitov, Musa, Kiselev, Ivan, Kulakova, Olga, Mamedov, Azad, Poroshina, Alina, Shilovskiy, Igor, Smirnov, Ivan, Sykulev, Yuri, Vlassov, Valentin, Vorobyeva, Nadezhda, Zakharova, Maria, Ziganshin, Rustam   +19 more
core   +1 more source