Results 101 to 110 of about 57,220 (227)

Influence of simvA glyzin on expression and inhibition of hmg-coa reductase in rats liver

Атеросклероз, 2015
Activity, level of protein and mRNA HMG-CoA reductase were investigated in rats liver treated with simvastatin (SV), its complex compound with glycyrrhizic acid – simvaglyzin (SVG) and glycyrrhizic acid alone.
Yu. I. Ragino, V. A. Vavilin, E. M. Stakhneva, N. F. Salakhutdinov, O. G. Safronova, A. B. Shintyapina, V. V. Lyakhovich, Yu. P. Nikitin   +7 more
doaj  

Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity

Heliyon, 2019
Objective: Bay leaf, one of the plants in Indonesia that has been shown to have activities to reduce cholesterol in the blood. HMG-CoA Reductase inhibition is one of many mechanisms in lowering the level of cholesterol in the blood. Here, we reported the
Lanny Hartanti, Stefania Maureen Kasih Yonas, Josianne Jacqlyn Mustamu, Sumi Wijaya, Henry Kurnia Setiawan, Lisa Soegianto   +5 more
doaj   +1 more source

Trust first, concerns second: An international vignette study of older adults' preferences towards deprescribing statins

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1509-1518, May 2026.
Abstract This study investigated the attitudes and beliefs of older adults towards deprescribing statins in Australia, the United Kingdom and the United States, using an online, vignette‐based study. Presented with a hypothetical scenario in which a general practitioner advised stopping simvastatin, participants rated their level of agreement and ...
Sarah E. Vordenberg, Noelia Dulo, Carissa Bonner, Eliza Ferguson, Vincent D. Marshall, Kristie Rebecca Weir   +5 more
wiley   +1 more source

APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1268-1286, May 2026.
Aim APOE genotype may affect statin therapy response. We conducted a meta‐analysis to update and quantify this association across various outcomes. Methods We searched seven databases (MEDLINE, Scopus, Web of Science, the Cochrane Library, APA PsycINFO, CINAHL Plus and ClinicalTrials.gov) on 9 May 2024.
Innocent G. Asiimwe, Tsegay Gebru, Andrea L. Jorgensen, Munir Pirmohamed, on behalf of the Multimorbidity Mechanism and Therapeutics Research Collaborative   +4 more
wiley   +1 more source

Effect of vitamin D3 derivatives on cholesterol synthesis and HMG-CoA reductase activity in cultured cells.

Journal of Lipid Research, 1989
Treatment of logarithmically growing rat intestinal epithelial cells (IEC-6) in culture with vitamin D3 (cholecalciferol), 25-hydroxy vitamin D3 (25-hydroxy cholecalciferol), 1,25-dihydroxy vitamin D3 (1,25-dihydroxycholecalciferol), and 24,25 dihydroxy ...
A K Gupta, R C Sexton, H Rudney
doaj   +1 more source

Hypoglycaemia Risk Prediction Models for Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This systematic review and meta‐analysis evaluated existing hypoglycaemia risk prediction models for Type 2 diabetes, finding excellent pooled discrimination (AUC = 0.815) but widespread high methodological bias, highlighting the need for rigorous model optimisation and external validation.
Yiwen Wei, Yu Liu, Jingwen Bo, Xiaoyan Bai   +3 more
wiley   +1 more source

Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver.

Journal of Lipid Research, 1981
To characterize further the behavior of the rate-limiting enzyme of cholesterol biosynthesis in animal species, we studied the kinetic properties and the influence of dietary lipid on intestinal and hepatic HMG-CoA reductase activity in the rabbit.
E F Stange, M Alavi, A Schneider, H Ditschuneit, J R Poley   +4 more
doaj   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, Volume 26, Issue 5, Page 86-97, May 2026.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone.

Journal of Lipid Research, 1984
The coordinated control of cholesterol biosynthesis and esterification by 25-hydroxycholesterol was studied in the macrophage-like cell line P388D1. Since 25-hydroxycholesterol rapidly stimulated incorporation of [3H]oleate into the cholesteryl ester ...
S C Miller, G Melnykovych
doaj   +1 more source