Results 1 to 10 of about 71,842 (286)
Myeloid cell-specific HMGB1 deficiency exaggerates mucoinflammatory responses but promotes bacterial clearance in mucoinflammatory lung disease [PDF]
Scientific ReportsHigh mobility group box 1 (HMGB1), a highly conserved nuclear protein, is released into the extracellular milieu serving as a modulator of inflammatory responses. HMGB1 levels are elevated in the airspaces of CF patients and mice with cystic fibrosis (CF)
Yun Mao, Sonika Patial, Yogesh Saini
doaj +2 more sources
Inflammatory signaling of HMGB1 in depressive disorder
Stress and Brain, 2023 Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang +4 more
doaj +1 more source
Virulence, 2021 High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases.
Wenqing Fan +3 more
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Journal of Behçet Uz Children's Hospital, 2023 Objective: Familial Mediterranean fever (FMF) is an autoinflammatory disease that commonly presents with fever, peritonitis, and pleuritis. Recent studies have reported ongoing inflammation in the attack-free period of patients with FMF.
Betül Öztürk +5 more
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Медицинская иммунология, 2022 Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel +8 more
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Integrative Atherosclerosis Treatment: Harnessing Herbal and Synthetic HMGB1 Inhibitors [PDF]
Research Journal of PharmacognosyHuman group box protein 1 (HMGB1) is a nuclear protein critical in various cellular processes. It is released in response to stress, infection, or tissue damage and acts as a danger signal, triggering immunological responses.
Ceaser Wankumbu Silumbwe* +6 more
doaj +1 more source
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]
, 2017 Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed +10 more
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Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
core +1 more source
From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis [PDF]
, 2018 Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis.
Alessandra Zicari +9 more
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Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Acland +49 more
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