Results 151 to 160 of about 32,692 (251)

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis. [PDF]

Clin Exp Dent Res
Afshar Y, Rezaei N.
europepmc   +1 more source

ZC3H13‐mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti‐PD‐1 response in HNSCC

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ZC3H13 promotes HNSCC progression and anti‐PD‐1 resistance by enhancing IGF2BP1‐mediated stabilization of CCND1 mRNA in an m6A‐dependent manner. Targeting ZC3H13 suppresses oral tumorigenesis and improves response to PD‐1 blockade. Abstract Background Resistance to immune checkpoint blockade substantially limits its clinical efficacy in head and neck ...
Wenqing Chen, Yun Li, Shuang Chen, Caihua Zhang, Zhi Liu, Kai Sun, Yingyi Li, Chunlong Yang, Wenbin Lei, Kang Li   +9 more
wiley   +1 more source

SFXN3 Serves as a Predictive Biomarker for Cisplatin Response and Survival in Head and Neck Squamous Cell Carcinoma. [PDF]

Oncol Res
Jeong EJ, Kim YS, Lee Y, Ryu JS, Choi YH, Kim E.   +5 more
europepmc   +1 more source

A Tale of Two Mechanisms: The p53 Modulator COTI‐2 Is a Zn Metallochaperone

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. Tp53 mutations often induce conformational changes that inhibit activity; however, small‐molecule chaperones could theoretically restore conformation and activity. COTI‐2,
İrem Şimşek, Farsheed Shahbazi‐Raz, Michael J. Krause, Azam Mohammadzadeh, Maryam Kosar, Peihan Xu, Samra Khan, Olena Tykhoniuk, Ashley DaDalt, Deya'a Almasri, Lara K. Watanabe, Kaitlyn Breault, John J. Hayward, Fraser S. Pick, Richard L. Ho, Jeremy M. Rawson, John F. Trant   +16 more
wiley   +1 more source

Th17-mediated antitumor immunity in patient-derived organoid and autologous immune cell cocultures predicts response to immunotherapy in head and neck cancer. [PDF]

Immunooncol Technol
Meißner P, Kaps P, Momper T, Wolff A, Raabe I, Strueder DF, Langenkamp U, Brandstetter J, Junghanss C, Becker AS, Zimpfer A, Maletzki C.   +11 more
europepmc   +1 more source

Different Pattern of Treatment Failure After Chemoradiation Between p16+ and p16− Patients Affected by Oropharyngeal Carcinoma

Head &Neck, Volume 48, Issue 8, Page 2048-2056, August 2026.
ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili, Paolo Bossi, Luca Lalli, Lisa Francesca Linda Licitra, Marta Maddalo, Almalina Bacigalupo, Liliana Belgioia, Jon Cacicedo, Nadia Facchinetti, Almudena Garcia Castano, Marc Oliva, Pierluigi Bonomo, Giuseppe Sanguineti, Pierfrancesco Franco, Athanassios Argiris, Amanda Psyrri, Ester Orlandi   +16 more
wiley   +1 more source

Comprehensive analysis and validation of the prognostic value of glycosylation- and mitophagy-related genes for head and neck squamous cell carcinoma. [PDF]

Transl Cancer Res
Lu Q, Ying L, Ling L, Hui W, Wang X.
europepmc   +1 more source

Disease Site‐Specific Outcomes in p16‐Positive Non‐Oropharyngeal Mucosal Head and Neck Cancer

Head &Neck, Volume 48, Issue 8, Page 2156-2169, August 2026.
ABSTRACT Objectives To report disease‐free survival (DFS) in p16‐positive non‐oropharyngeal head‐and‐neck squamous‐cell carcinoma (HNSCC). Methods Curatively‐treated non‐oropharyngeal HNSCC (2009–2021) were reviewed. DFS was compared among p16‐positive, p16‐negative, and p16‐untested cases for the overall cohort and by disease site.
Revadhi C. Chelvarajah, Lessandra Y. S. Chee, Jie Su, Brian O'Sullivan, Christopher M. K. L. Yao, Enrique Sanz‐Garcia, Stephen M. Smith, Ilan Weinreb, Scott Bratman, B. C. John Cho, Ezra Hahn, Andrew Hope, Ali Hosni, John Kim, Andrew McPartlin, Nauman Malik, Chiaojung Jillian Tsai, John de Almeida, Anna Spreafico, Li Tong, Shao Hui Huang, John N Waldron   +21 more
wiley   +1 more source

Methylation-regulated miR-374a-5p and miR-374b-5p suppress glycolysis and malignant progression of head and neck squamous cell carcinoma by targeting DEPDC1. [PDF]

Front Oncol
Zhang L, Lu Y, Qin C, Gu H, Du J, Guo H, Wang P, Wu Y, Gao W.   +8 more
europepmc   +1 more source

Tumor Growth Rate in Head and Neck Squamous Cell Carcinoma: A Scoping Review

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objective This scoping review evaluates the current literature on tumor growth rate in head and neck cancer patients and its potential prognostic value on survival, loco‐regional control and recurrence (PROSPERO registration CRD42022370828). Review Methods PubMed, Embase, and Scopus were searched for publications between 1990 and November 5th ...
Gilles Delahaut, Florent Jamme, Bruno Krug, Jean‐François Daisne, Samantha Hassid, Sebastien Van der Vorst   +5 more
wiley   +1 more source