Results 141 to 150 of about 25,300,433 (384)

Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway

Molecules, 2012
Intestinal ischemia reperfusion (IIR) is a serious clinical condition associated with simultaneous multiple organ dysfunction. The aim of this study was to investigate the effects of ginsenoside Rb1 on IIR induced renal injury in mice.
Zhong-Yuan Xia, Qian Sun, Ying Jiang, Qing-Tao Meng   +3 more
doaj   +1 more source

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

Oxidative Medicine and Cellular Longevity, 2019
Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI),
Gloria E Villalpando-Rodriguez, Anna R Blankstein, Carmen Konzelman, S. Gibson   +3 more
semanticscholar   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis

, 2016
Angiogenesis is an essential physiological process and an important factor in disease pathogenesis. However, its exploitation as a clinical target has achieved limited success and novel molecular targets are required.
Bauer, A, Birdsey, G, Calay, D, Kiprianos, A, Mason, JC, Mayr, M, Mylroie, H, Randi, A, Soares, MP, Thornton, C, Wilson, GK, Yin, X   +11 more
core   +1 more source

New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases

Oxidative Medicine and Cellular Longevity, 2019
Respiratory diseases are one of the most common pediatric diseases in clinical practice. Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation.
Xueyan Zhang, Ming Ding, P. Zhu, Huanlei Huang, Zhuang Quan, Jie Shen, Yufeng Cai, Mingyi Zhao, Qingnan He   +8 more
semanticscholar   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells [PDF]

, 2008
The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and nitric oxide (NO).
Durante, William, Liu, Xiao-Ming, Mendelev, Natalia N., Peyton, Kelly J., Tulis, David A., Wang, Hong   +5 more
core   +2 more sources

1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway

Journal of Inflammation Research, 2021
Arooj Mohsin Alvi,1,2 Fawad Ali Shah,2 Asmaa Jan Muhammad,2 Jinxing Feng,1 Shupeng Li3 1Department of Neonatology, Shenzhen Children’s Hospital Shenzhen, Shenzhen, People’s Republic of China; 2Department of Pharmacology, Riphah Institute of ...
Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S   +4 more
doaj  

A Raroc Valuation Scheme for Loans and Its Application in Loan Origination

Risks, 2020
In this article, a risk-adjusted return on capital (RAROC) valuation scheme for loans is derived. The critical assumption throughout the article is that no market information on a borrower’s credit quality like bond or CDS (Credit Default Swap) spreads ...
Bernd Engelmann, Ha Pham
doaj   +1 more source

Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway

Aging, 2018
After 480 days of age, high-producing hens are likely to be subject to ovarian aging, mainly due to oxidative stress. In this study, the amelioration of ovarian aging in chickens, using a plant antioxidant, lycopene, was investigated. The activity of the
Xing-ting Liu, Xin Lin, Siyu Zhang, Changquan Guo, Jian Li, Y. Mi, Caiqiao Zhang   +6 more
semanticscholar   +1 more source