Results 81 to 90 of about 6,534 (190)
Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang +9 more
wiley +1 more source
Kansainvälistä diplomatiaa Holin syysseminaarissa 2019
Henna Harju
doaj +1 more source
Analysis of 58 Families of Holins Using a Novel Program, PhyST [PDF]
We have designed a freely accessible program, PhyST, which allows the automated characterization of any family of homologous proteins within the Transporter Classification Database. The program performs an NCBI-PSI-BLAST search and reports (1) the average protein sequence length with standard deviations, (2) the average predicted number of ...
Kuppusamykrishnan, Harikrishnan +3 more
openaire +4 more sources
The recombinant endolysin El1 derived from Enterobacteria bacteriophages showed potent bactericidal activity against Gram‐negative bacteria when applied exogenously, even in the absence of membrane‐permeabilizing agents, such as ethylenediaminetetraacetic acid (EDTA).
Tatjana Kazaka +6 more
wiley +1 more source
Defense Systems and Prophage Detection in Streptococcus mutans Strains
ABSTRACT Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages in the genomes of clinical isolates of S. mutans using bioinformatics tools.
Olivier Claisse +3 more
wiley +1 more source
Summary Gram‐positive bacterial extracellular membrane vesicles (EVs) have been drawing more attention in recent years. However, mechanistic insights are still lacking on how EVs are released through the cell walls in Gram‐positive bacteria.
Yue Liu +5 more
doaj +1 more source
Functional Evaluation of a Conserved HNH Endonuclease Gene in Lactococcal Skunavirus Genomes
The HNH endonuclease HrdP is a highly conserved and essential determinant of infectivity among Skunavirus phages, specifically required for the successful completion of DNA packaging. This key role highlights HrdP as a promising and specific anti‐phage target to protect dairy starter cultures from failure.
Jun‐Hyeok Yu +7 more
wiley +1 more source
A. Constructs used for holin expression under the control of the late transcription regulatory (LTR) elements of phage λ. The promoter pR′ and the transcriptional terminator tR′ of the λ LTR region are depicted as a bent arrow and a hairpin structure ...
Bruno Dupuy (159473) +1 more
core +1 more source
What makes the lysis clock tick? A study of the bacteriophage holin [PDF]
The timing of host lysis is the only decision made in the bacteriophage lytic cycle. To optimize timing, double-stranded DNA phages use a 2-component lysis system consisting of a muralytic enzyme, the endolysin, and a small membrane protein, the holin ...
White, Rebecca Lynn
core
The effect of holin mutation on eDNA and biofilm matrix production.
(A) Production of eDNA by P. chlororaphis 30–84 wild type and the holin mutant after growing 48 and 72 hr in static culture. (B) Biofilm matrix production by 30–84 wild type and the holin mutant at 72 h.
Dongping Wang (134633) +4 more
core +1 more source

