Characterization of Holins, the Membrane Proteins of Coliphage ASEC2201: A Genomewide in Silico Approach [PDF]
Frontiers in MicrobiologyDrug-resistant Escherichia coli poses a significant healthcare burden, driving the search for novel antimicrobials. We have previously done the isolation and whole-genome sequencing of ASEC2201, a novel coliphage derived from multidrug-resistant clinical
Mirza Masroor Ali Beg, Aditi Singh
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Frontiers in Microbiology, 2022 Holins and spanins are bacteriophage-encoded membrane proteins that control bacterial cell lysis in the final stage of the bacteriophage reproductive cycle.
Renwick Dobson, Craig Billington
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Analysis of 58 Families of Holins Using a Novel Program, PhyST [PDF]
Journal of Molecular Microbiology and Biotechnology, 2016 We have designed a freely accessible program, PhyST, which allows the automated characterization of any family of homologous proteins within the Transporter Classification Database.
Milton H Saier, Gabriel Moreno-Hagelsieb
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Biological Functional Identification of Holins From Salmonella Pullorum Phages and Their Therapeutic Efficacy Against Pullorum Disease in Chickens [PDF]
Poultry ScienceSalmonella pullorum (S.pullorum) is a significant pathogen that seriously endangers the poultry industry. However, its prevention and control mainly rely on antibiotics, which leads to the wide spread of drug-resistant genes and poses a serious public ...
Yanping Jiang, Yingying Ma, Wen Cui
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Spatial and temporal control of lysis by the lambda holin
mBio, 2023 The infection cycle of phage λ terminates in lysis mediated by three types of lysis proteins, each disrupting a layer in the bacterial envelope: the S105 holin, the R endolysin, and the Rz/Rz1 spanin complex targeting the inner membrane, cell wall or ...
Jesse Cahill +8 more
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The Staphylococcus aureus CidA and LrgA Proteins Are Functional Holins Involved in the Transport of By-Products of Carbohydrate Metabolism [PDF]
mBio, 2022 The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD).
Jennifer L. Endres +9 more
doaj +3 more sources
The short cytoplasmic region of phage T4 holin is essential for the transition from impermeable membrane protein complexes to permeable pores [PDF]
Frontiers in MicrobiologyVirulent as well as temperate phages usually require lysis of bacteria to release their progeny into the surrounding. Double-stranded DNA phages achieve lysis by phage-encoded endolysins that degrade the bacterial cell wall.
Jan Michel Frederik Schwarzkopf +5 more
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Cell death dependent on holins LrgAB repressed by a novel ArsR family regulator CdsR
Cell Death DiscoveryThe cell death and survival paradox in various biological processes requires clarification. While spore development causes maternal cell death in Bacillus species, the involvement of other cell death pathways in sporulation remains unknown.
Xin Zhang +8 more
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Phage-Encoded Lysis Proteins (Holins and Spanins): Mechanisms and Emerging Applications
PhageHolins and spanins are bacteriophage-encoded enzymes that control the onset and efficiency of bacterial cell lysis in the late stage of the bacteriophage life cycle.
Hamidreza Abtahi, Farzaneh Kianian
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PLoS ONE, 2022 Holins are bacteriophage-encoded transmembrane proteins that function to control the timing of bacterial lysis event, assist with the destabilization of the membrane proton motive force and in some models, generate large "pores" in the cell membrane to ...
Richard S Pollenz +2 more
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