Results 41 to 50 of about 2,686 (200)

External factors influence intrinsic differences in Stx2e production by Porcine Shiga Toxin-producing Escherichia coli strains. [PDF]

PLoS Pathogens
Porcine Shiga toxin-producing Escherichia coli (STEC) strains pose significant challenges to the pig industry. The toxins produced by these strains, particularly Shiga toxin subtype 2e (Stx2e), are associated with a range of clinical symptoms such as ...
Sander Van Hoorde, Nick Vereecke, Daniel Sperling, Xiaohua He, Emma Vanbeylen, Emma Van Denberghe, Eric Cox, Bert Devriendt   +7 more
doaj   +2 more sources

Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release [PDF]

Proc Natl Acad Sci U S A
Most bacteriophages lyse their host cell to release progeny virions. Double-stranded DNA phages typically promote host lysis using a holin-endolysin system. Holins form pores in the cytoplasmic membrane allowing endolysins access to the peptidoglycan (PG)
Amelia C. McKitterick, Evan Lyerly, T. Bernhardt   +2 more
semanticscholar   +2 more sources

Topological dynamics of holins in programmed bacterial lysis [PDF]

Proceedings of the National Academy of Sciences, 2006
The fate of phage-infected bacteria is determined by the holin, a small membrane protein that triggers to disrupt the membrane at a programmed time, allowing a lysozyme to attack the cell wall. S 21 68, the holin of phage 21, has two transmembrane domains (TMDs) with a predicted N-in, C-in ...
Taehyun Park, D. Struck, John Deaton, R. Young   +3 more
semanticscholar   +3 more sources

Decoding the Molecular Properties of Mycobacteriophage D29 Holin Provides Insights into Holin Engineering [PDF]

Journal of Virology, 2021
Holins are bacteriophage-encoded small membrane perforators that play an important role in determining the timing of host cell lysis toward the end of the phage infection cycle. The ability of holin to precisely time the hole formation in the cell membrane, ensuring cell lysis, is both interesting and intriguing.
Varun Rakeshbhai Bavda, Aditi Yadav, Vikas Jain   +2 more
openaire   +2 more sources

Unlocking the Potential of vB_EfaS_LOK1: A Newly Isolated Bacteriophage Against Enterococcus faecalis [PDF]

Microorganisms
Phage therapy has emerged as a promising alternative for combating infections caused by drug-resistant pathogens. Among these, Enterococcus faecalis remains a significant public health concern due to its persistence in clinical settings and frequent ...
Laura Marcela Plata Suarez, Salvador Del Valle Balbuena, Isamar Leticia Becerra Mejía, Alejandra Aidee Loera Piedra, Cristina Domínguez Espinoza, Arantxa Monserrat Ángeles González, Araceli Contreras Rodríguez, Alejandra Aquino Andrade, Sergio Francisco Martínez Díaz, Ma. Guadalupe Aguilera Arreola   +9 more
doaj   +2 more sources

A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridium sordellii

Toxins, 2022
Protein secretion is generally mediated by a series of distinct pathways in bacteria. Recently, evidence of a novel bacterial secretion pathway involving a bacteriophage-related protein has emerged.
Callum J. Vidor, Audrey Hamiot, Jessica Wisniewski, Rommel A. Mathias, Bruno Dupuy, Milena Awad, Dena Lyras   +6 more
doaj   +1 more source

Dimerization between the Holin and Holin Inhibitor of Phage λ [PDF]

Journal of Bacteriology, 2000
ABSTRACT Holins are integral membrane proteins that control the access of phage-encoded muralytic enzymes, or endolysins, to the cell wall by the sudden formation of an uncharacterized homo-oligomeric lesion, or hole, in the membrane, at a precisely defined time. The timing of λ-infected cell lysis depends solely on the 107 codon
Gründling, Angelika, Smith, David L., Bläsi, Udo, Young, Ry   +3 more
openaire   +3 more sources

The Phage T4 Antiholin RI Has a Cleavable Signal Peptide, Not a SAR Domain

Frontiers in Microbiology, 2021
Holin/endolysin-mediated lysis of phage T4 of Escherichia coli is tightly regulated by the antiholins RI and RIII. While regulation by the cytoplasmic RIII plays a minor role, the periplasmic antiholin RI binds tightly to the holin T and is believed to ...
Denise Mehner-Breitfeld, Jan Michel Frederik Schwarzkopf, Ry Young, Kiran Kondabagil, Thomas Brüser   +4 more
doaj   +1 more source

Holin triggering in real time [PDF]

Proceedings of the National Academy of Sciences, 2010
During λ infections, the holin S105 accumulates harmlessly in the membrane until, at an allele-specific time, suddenly triggering to form irregular holes of unprecedented size (>300 nm), releasing the endolysin from the cytoplasm, resulting in lysis within seconds.
Rebecca, White, Shinobu, Chiba, Ting, Pang, Jill S, Dewey, Christos G, Savva, Andreas, Holzenburg, Kit, Pogliano, Ry, Young   +7 more
openaire   +2 more sources

Deciphering the Role of Holin in Mycobacteriophage D29 Physiology [PDF]

Frontiers in Microbiology, 2020
In the era of antibiotic resistance, phage therapy is gaining attention for the treatment of pathogenic organisms such as Mycobacterium tuberculosis. The selection of phages for therapeutic purposes depends upon several factors such as the host range that a phage can infect, which can be narrow or broad, time required for the host cell lysis, and the ...
Varun Rakeshbhai Bavda, Vikas Jain
openaire   +3 more sources