Results 31 to 40 of about 2,686 (200)

Three Novel Bacteriophages, J5a, F16Ba, and z1a, Specific for Bacillus anthracis, Define a New Clade of Historical Wbeta Phage Relatives

Viruses, 2022
Bacillus anthracis is a potent biowarfare agent, able to be highly lethal. The bacteria dwell in the soil of certain regions, as natural flora.
Aleksandra Nakonieczna, Paweł Rutyna, Magdalena Fedorowicz, Magdalena Kwiatek, Lidia Mizak, Małgorzata Łobocka   +5 more
doaj   +2 more sources

Synergistic action of phages and lytic proteins with antibiotics: a combination strategy to target bacteria and biofilms

BMC Microbiology, 2023
Background Multidrug-resistant bacteria continue to emerge owing to the abuse of antibiotics and have a considerable negative impact on people and the environment. Bacteria can easily form biofilms to improve their survival, which reduces the efficacy of
Han Lu, Zong Li, Amro Elbaz, Shou-Qing Ni   +3 more
doaj   +2 more sources

The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier [PDF]

Journal of Xenobiotics
The lack of new antibacterial medicines and the rapid rise in bacterial resistance to antibiotics pose a major threat to individuals and healthcare systems.
Abdus Sabur, Angkan Khan, B. Borphukan, Abdur Razzak, M. Salimullah, Muslima Khatun   +5 more
doaj   +2 more sources

Biological function identification of phage holin Hol-4086 and treatment of Staphylococcus aureus infection

Frontiers in Microbiology
The treatment of infections caused by drug-resistant Staphylococcus aureus has become increasingly difficult. In this study, the complete genome of phage 4086-1 against S. aureus was sequenced and shown to be 17,960 bp in size, with a GC content of 29.14%
Chenyu Zheng, Yaxin Di, Yingchun Wang, Huyang Zhao, Ruichong Wang, Guiwei Li, Xiaona Wang, Zhifu San, Yanping Jiang, Wen Cui, Jiaxuan Li, Li Wang, Xinyuan Qiao   +12 more
doaj   +2 more sources

Stable micron-scale holes are a general feature of canonical holins [PDF]

Molecular Microbiology, 2013
At a programmed time in phage infection cycles, canonical holins suddenly trigger to cause lethal damage to the cytoplasmic membrane, resulting in the cessation of respiration and the non‐specific release of pre‐folded, fully active endolysins to the ...
C. Savva, J. Dewey, Samir H. Moussa, Kameneva To, A. Holzenburg, R. Young   +5 more
semanticscholar   +3 more sources

Prophage-Derived Molecules as Anti-Vibrio Agents in Aquaculture: Mechanisms of Biofilm Control and Virulence Suppression [PDF]

Antibiotics
Vibriosis causes substantial losses in marine and brackish-water aquaculture, while increasing antimicrobial resistance limits the effectiveness of conventional antibiotic treatment.
Nazia Tabassum, Aqib Javaid, Abirami Karthikeyan, Minji Kim, Young-Mog Kim, Fazlurrahman Khan   +5 more
doaj   +2 more sources

The lysis mechanism of the haloarchaeal virus HFTV1

Cell Reports
Summary: Tailed bacteriophages can lyse their host with help of the holin-endolysin system. However, for archaeal tailed viruses (arTVs), whose archaeal hosts have a fundamentally different cell envelope, lysis mechanisms are unknown.
Bastiaan P. Kuiper, Marco P.A. van Tilburg, Leonard E. Bäcker, Sourav Maity, Yogy S. Ariyanto, Joshua G. Petters, Zaloa Aguirre-Sourrouille, Jeroen G. Nijland, Harma Karsens, Greetje A. Berrelkamp-Lahpor, Colin Tittes, Johanna Wiechert, Julia Frunzke, Bertram Daum, Wouter H. Roos, Siewert-J. Marrink, Tessa E.F. Quax   +16 more
doaj   +2 more sources

A Clostridioides difficile endolysin modulates toxin secretion without cell lysis

Communications Biology
The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion.
Milena M. Awad, Chathura D. Suraweera, Callum J. Vidor, Auberon Y. Ye-Lin, Galain C. Williams, Steven J. Mileto, Christopher K. Barlow, Sheena McGowan, Dena Lyras   +8 more
doaj   +2 more sources

Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development

BioDesign Research
The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial agents.
Wakana Yamashita, Shinjiro Ojima, Azumi Tamura, Aa Haeruman Azam, Kohei Kondo, Zhang Yuancheng, Longzhu Cui, Masaki Shintani, Masato Suzuki, Yoshimasa Takahashi, Koichi Watashi, Satoshi Tsuneda, Kotaro Kiga   +12 more
doaj   +2 more sources

Comparative genomics reveals diversity and taxonomic relationships among Clostridioides difficile phages [PDF]

Microbiology Spectrum
Clostridioides difficile is associated with life-threatening antibiotic-associated diarrhea, colitis, and toxin-mediated infections. While antibiotics are the primary treatment against C.
Mohimenul Haque Rolin, Shakhinur Islam Mondal, Daniyal Karim, Nurnabi Azad Jewel, Tahsin Khan, Mustafizur Rahman, Arzuba Akter   +6 more
doaj   +2 more sources