Results 71 to 80 of about 6,534 (190)

Characterization of the dual start motif of a class II holin gene [PDF]

Molecular Microbiology, 1999
Holins are small membrane proteins that, at a genetically programmed time in a bacteriophage infective cycle, allow bacteriolytic enzymes, or endolysins, to escape to the periplasm and to attack the cell wall. Most holins fall into two sequence classes, I and II, based on the number of potential transmembrane domains (three for class I and two for ...
M, Barenboim, C Y, Chang, F, dib Hajj, R, Young   +3 more
openaire   +2 more sources

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

The “White-Eyed” Player Culture: Grief Play and Construction of Deviance in MMORPGs

, 2005
Contact: Holin Lin, Department of Sociology at National Taiwan University, holin@ntu.edu ...
Sun, Chuen-Tsai, Lin, Holin, Chuen-Tsai Sun, Holin Lin   +3 more
core   +1 more source

The Serratia marcescens NucE protein functions as a holin in Escherichia coli [PDF]

Journal of Bacteriology, 1997
The recently discovered nucC locus of Serratia marcescens encodes the cryptic prophage genes nucE, nucD, and nucC. NucC is required for expression of the S. marcescens nuclease and functions as a transcriptional activator of the nuclease gene, nucA. NucE and NucD are dispensable for nuclease expression but were proposed to allow for secretion of the ...
M, Berkmen, M J, Benedik, U, Bläsi
openaire   +2 more sources

New Finnlakevirus Isolate FLiP‐2 Provides Insight Into the Ecology of ssDNA Phages in Flavobacterium Hosts

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Despite the small genome size, ssDNA virus FLiP is remarkably well adapted to the seasonal variations of boreal fresh waters demonstrating excellent condition and host specific flexibility in its host interactions. FLiP plaques detected far from the original infection site represent a previously undescribed phenomenon, likely caused by the phage non ...
Kati Mäkelä, Elina Laanto, Reetta Penttinen, Janne Ravantti, Kim Kreuze, Lotta‐Riina Sundberg   +5 more
wiley   +1 more source

Identification and in vitro Characterization of a Novel Phage Endolysin that Targets Gram-Negative Bacteria

Microorganisms, 2020
Most double-stranded (ds) DNA phages utilize holin proteins to secrete endolysin for host peptidoglycan lysis. In contrast, several holin-independent endolysins with secretion sequences or signal-arrest-release (SAR) sequences are secreted via the Sec ...
Jaewoo Bai, Sangmi Lee, Sangryeol Ryu
doaj   +1 more source

Stable micron‐scale holes are a general feature of canonical holins [PDF]

Molecular Microbiology, 2013
SummaryAt a programmed time in phage infection cycles, canonical holins suddenly trigger to cause lethal damage to the cytoplasmic membrane, resulting in the cessation of respiration and the non‐specific release of pre‐folded, fully active endolysins to the periplasm. For the paradigm holin S105 of lambda, triggering is correlated with the formation of
Christos G, Savva, Jill S, Dewey, Samir H, Moussa, Kam H, To, Andreas, Holzenburg, Ry, Young   +5 more
openaire   +2 more sources

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Extracellular vesicle production in Gram‐positive bacteria

Microbial Biotechnology, 2022
Summary This is a highlight on the article ‘Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage‐encoded holin‐lysin system’ by Yue Liu, Eddy Smid and Tjakko Abee.
Scott N. Dean, Meghna Thakur, Joseph R. Spangler   +2 more
doaj   +1 more source

Topological and phylogenetic analyses of bacterial holin families and superfamilies

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Holins are small "hole-forming" transmembrane proteins that mediate bacterial cell lysis during programmed cell death or following phage infection. We have identified fifty two families of established or putative holins and have included representative members of these proteins in the Transporter Classification Database (TCDB; www.tcdb.org).
Reddy, Bhaskara L, Saier, Milton H
openaire   +4 more sources