Results 101 to 110 of about 2,686 (200)

Characterisation of a Novel Jumbo Lytic Aeromonas dhakensis Bacteriophage P19 and Its Endolysin

open access: yesMicrobial Biotechnology, Volume 19, Issue 1, January 2026.
A jumbo, lytic myovirus phage P19 against multidrug‐resistant (MDR) Aeromonas dhakensis was isolated from river water. P19 demonstrated robust lytic activity, high thermal and pH stability (pH 6–10, up to 60°C), and no genes associated with lysogeny, virulence or antimicrobial resistance. ORF_358 of P19 encodes for T4‐type lysozyme.
Farhat Ansari, Vandan Nagar
wiley   +1 more source

Harnessing Viruses Against Multidrug‐Resistant Bacteria: Exploring the Potential of Bacteriophage‐Based Drug Discovery

open access: yesAdvanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
The global escalation of multidrug‐resistant (MDR) bacteria necessitates alternative antimicrobial strategies beyond conventional antibiotics. Bacteriophage therapy has re‐emerged as a promising intervention, offering targeted bacterial killing with minimal disruption to host microbiota. This review evaluates the therapeutic potential of bacteriophages
Doofan Bur   +5 more
wiley   +1 more source

Viruses that heal: harnessing bacteriophages in the era of antibiotic resistance

open access: yesВопросы вирусологии
The global rise in antimicrobial resistance (AMR) poses an urgent threat to public health, and novel alternatives to traditional antibiotics are needed. One of the most promising options is bacteriophages, viruses that infect and destroy bacteria.
Theresa A. Awotundun   +2 more
doaj   +1 more source

Effect of the Clostridium Difficile TCDE Protein on Membranes of Escherichia Coli [PDF]

open access: yes, 2014
Clostridium difficile infects millions of hospitalized patients worldwide, causing pseudomembranous colitis, a disease with symptoms attributable to two toxins produced by the bacterium.The PaLoc gene locus in the C.
Hollenberg, Sophie
core   +3 more sources

Bacteria- and Phage-Derived Proteins in Phage Infection

open access: yesFrontiers in Bioscience-Landmark
Phages have exerted severe evolutionary pressure on prokaryotes over billions of years, resulting in major rearrangements. Without every enzyme involved in the phage–bacterium interaction being examined; bacteriophages cannot be used in practical ...
Olga I. Guliy, Stella S. Evstigneeva
doaj   +1 more source

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile

open access: yes, 2023
Abstract Clostridioides difficile is the leading cause of healthcare associated infections. The Pathogenicity Locus (PaLoc) toxins TcdA and TcdB promote host disease. These toxins lack canonical N-terminal signal sequences for translocation across the bacterial membrane, suggesting alternate ...
NV DiBenedetto   +6 more
openaire   +2 more sources

From Powder to Pathogen: A Systematic Review of Detection, Pathogenicity, and Mitigation of Cronobacter sakazakii in Infant Formula

open access: yesInternational Journal of Microbiology, Volume 2026, Issue 1, 2026.
Cronobacter sakazakii is an emerging foodborne pathogen that has gained increasing global attention due to its association with severe infections in neonates, particularly meningitis, sepsis, and necrotizing enterocolitis. These infections are often associated with contaminated powdered infant formula (PIF), a nonsterile but commonly used alternative ...
Sutapa Bhowmik   +8 more
wiley   +1 more source

Characterization of Sinorhizobium sp. LM21 Prophages and Virus-Encoded DNA Methyltransferases in the Light of Comparative Genomic Analyses of the Sinorhizobial Virome

open access: yesViruses, 2017
The genus Sinorhizobium/Ensifer mostly groups nitrogen-fixing bacteria that create root or stem nodules on leguminous plants and transform atmospheric nitrogen into ammonia, which improves the productivity of the plants. Although these biotechnologically-
Przemyslaw Decewicz   +2 more
doaj   +1 more source

Bacteriophage lysis: mechanism and regulation

open access: yesMicrobiological reviews, 1992
Bacteriophage lysis involves at least two fundamentally different strategies. Most phages elaborate at least two proteins, one of which is a murein hydrolase, or lysin, and the other is a membrane protein, which is given the designation holin in this ...
R. Young
semanticscholar   +1 more source

Comparative genomics of four closely related Clostridium perfringens bacteriophages reveals variable evolution among core genes with therapeutic potential

open access: yesBMC Genomics, 2011
Background Because biotechnological uses of bacteriophage gene products as alternatives to conventional antibiotics will require a thorough understanding of their genomic context, we sequenced and analyzed the genomes of four closely related phages ...
Siragusa Gregory R   +6 more
doaj   +1 more source

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