Results 81 to 90 of about 2,686 (200)

Chitinase A, a tightly regulated virulence factor of Salmonella enterica serovar Typhimurium, is actively secreted by a Type 10 Secretion System.

open access: yesPLoS Pathogens, 2023
As a facultative intracellular pathogen, Salmonella enterica serovar Typhimurium is one of the leading causes of food-borne diseases in humans. With the ingestion of fecal contaminated food or water, S. Typhimurium reaches the intestine.
Lena Krone   +4 more
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun   +19 more
wiley   +1 more source

Prophage WO encodes a putative lytic cassette.

open access: yes, 2022
Adjacent to the tail module of most prophage WO variants are three phage lysis candidates: ankyrin repeat containing protein (not shown), holin-like, and patatin-like phospholipase.
Sarah R. Bordenstein (7365494)   +1 more
core   +1 more source

New Finnlakevirus Isolate FLiP‐2 Provides Insight Into the Ecology of ssDNA Phages in Flavobacterium Hosts

open access: yesEnvironmental Microbiology, Volume 28, Issue 6, June 2026.
Despite the small genome size, ssDNA virus FLiP is remarkably well adapted to the seasonal variations of boreal fresh waters demonstrating excellent condition and host specific flexibility in its host interactions. FLiP plaques detected far from the original infection site represent a previously undescribed phenomenon, likely caused by the phage non ...
Kati Mäkelä   +5 more
wiley   +1 more source

The Staphylococcus Aureus lrgAB Operon Encodes a Holin-Like Protein Involved in Pyruvate Transport [PDF]

open access: yes, 2021
The Staphylococcus aureus cidABC and lrgAB operons encode a well-conserved family of proteins involved in programmed cell death (PCD) during biofilm development.
Endres, Jennifer L.
core  

Characterization and determination of holin protein of Streptococcus suis bacteriophage SMP in heterologous host

open access: yesVirology Journal, 2012
Background Holins are a group of phage-encoded membrane proteins that control access of phage-encoded endolysins to the peptidoglycan, and thereby trigger the lysis process at a precise time point as the 'lysis clock'.
Shi Yibo   +6 more
doaj   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao   +6 more
wiley   +1 more source

Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE. [PDF]

open access: yesPLoS Pathogens, 2012
The pathogenesis of Clostridium difficile, the major cause of antibiotic-associated diarrhea, is mainly associated with the production and activities of two major toxins.
Revathi Govind, Bruno Dupuy
doaj   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang   +9 more
wiley   +1 more source

Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2

open access: yesVirology Journal, 2023
Background Bacteriophages (phages) are one of the most promising alternatives to traditional antibiotic therapies, especially against multidrug-resistant bacteria.
Mohamed S. Fayez   +8 more
doaj   +1 more source

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