Results 71 to 80 of about 2,686 (200)

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

Whole-Genome Analysis Reveals That Bacteriophages Promote Environmental Adaptation of Staphylococcus aureus via Gene Exchange, Acquisition, and Loss

Viruses, 2022
The study of bacteriophages is experiencing a resurgence owing to their antibacterial efficacy, lack of side effects, and low production cost. Nonetheless, the interactions between Staphylococcus aureus bacteriophages and their hosts remain unexplored ...
Wenyuan Zhou, Hua Wen, Yajie Li, Yajun Gao, Xiangfeng Zheng, Lei Yuan, Guoqiang Zhu, Zhenquan Yang   +7 more
doaj   +1 more source

Mechanisms and Application of Bacteriophages in Regulating Intestinal Health of Livestock and Poultry

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Bacteriophages offer targeted, self‐limiting control of intestinal pathogens in livestock and poultry. This review integrates their biological properties, mechanisms of gut‐health promotion, key experimental evidence, application strategies, and current challenges, outlining a path toward sustainable animal production and global food security ...
Manman Song, Yuying Fan, Liguo Zhang, Wenhao Qi, Lin Li, Gang Zhao, Jianwei He   +6 more
wiley   +1 more source

Engineered endolysin-based “artilysins” for controlling the gram-negative pathogen Helicobacter pylori

AMB Express, 2021
Helicobacter pylori infection can cause a variety of gastrointestinal diseases. In severe cases, there is a risk of gastric cancer. Antibiotics are often used for clinical treatment of H. pylori infections.
Dengyuan Xu, Shanshan Zhao, Jun Dou, Xiaofeng Xu, Yanyan Zhi, Liangzhu Wen   +5 more
doaj   +1 more source

Identification and Mutational Analysis of Bacteriophage PRD1 Holin Protein P35 [PDF]

Journal of Bacteriology, 2003
ABSTRACT Holin proteins are phage-induced integral membrane proteins which regulate the access of lytic enzymes to host cell peptidoglycan at the time of release of progeny viruses by host cell lysis. We describe the identification of the membrane-containing phage PRD1 holin gene (gene XXXV ).
Pia S, Rydman, Dennis H, Bamford
openaire   +2 more sources

Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease

Annals of Neurology, Volume 100, Issue 2, Page 334-340, August 2026.
We conducted a nested case‐control study within the Nurses’ Health Study and the Health Professionals Follow‐up Study to examine the role of the gut virome (GV) in Parkinson's disease (PD). We applied a novel metagenomic virome profiling approach, Bioinformatic Application for Quantification and Labeling of Viral taxonomy (BAQLaVa), to prospectively ...
Deepika Dinesh, Xochitl C. Morgan, Jordan Jensen, Kjetil Bjornevik, Michael A. Schwarzschild, Alberto Ascherio, Curtis Huttenhower, Natalia Palacios   +7 more
wiley   +1 more source

Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile [PDF]

Journal of Medical Microbiology, 2001
Toxigenic strains of Clostridium difficile produce two large bacterial toxins called toxins A (TcdA) and B (TcdB). tcdA and tcdB genes are located on the pathogenicity locus of C. difficile, a unique characteristic of toxigenic strains of this species.
Kai Soo Tan, Boon Yu Wee, Keang Peng Song   +2 more
openaire   +2 more sources

Revisiting Burn Wound Infections: A Comprehensive Review on the Dual Potential of Phages and Probiotics Against Acinetobacter baumannii

Journal of Clinical Laboratory Analysis, Volume 40, Issue 16, August 2026.
Effect Probiotics on immune system modulation and wound Healing. ABSTRACT Introduction Burn wound infections caused by Acinetobacter baumannii remain a critical clinical challenge due to its extensive multidrug resistance, particularly against carbapenems.
Zeinab Fagheei Aghmiyuni, Shahrzad Aliniay Sharafshadehi, Roghayeh Afifirad, Elnaz Bafandeh, Maryam Mokhtaryan, Roya Ghanavati, Atieh Darbandi   +6 more
wiley   +1 more source

Characterization of the dual start motif of a class II holin gene [PDF]

Molecular Microbiology, 1999
Holins are small membrane proteins that, at a genetically programmed time in a bacteriophage infective cycle, allow bacteriolytic enzymes, or endolysins, to escape to the periplasm and to attack the cell wall. Most holins fall into two sequence classes, I and II, based on the number of potential transmembrane domains (three for class I and two for ...
M, Barenboim, C Y, Chang, F, dib Hajj, R, Young   +3 more
openaire   +2 more sources

Regenerative Microbiology: Harnessing Bacterial Antagonism and Spatiotemporal Signaling for Diabetic Wound Repair

Smart Medicine, Volume 5, Issue 4, August 2026.
This review introduces “Regenerative Microbiology,” a framework that uses bacterial antagonism and phage therapy to address diabetic wound dysbiosis. By activating the p40/EGFR/PI3K axis and providing a vascular‐stratified precision roadmap, this approach shifts the paradigm from antimicrobial suppression to intelligent, microbe‐driven tissue ...
Sabri Saeed Sanabani
wiley   +1 more source