Results 51 to 60 of about 119,108 (236)

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria [PDF]

, 2010
The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build ...
A Abzhanov, A Caracciolo, A Hejnol, A Hidalgo, A Horner, A Minelli, A Minelli, A Saudemont, A Schmidt-Rhaesa, A Wallberg, AD Chipman, AS Denes, B Hausdorf, B Mittmann, B Prud’homme, B Rhode, C Nielsen, Christopher J. Winchell, CJ Tabin, CJ Winchell, CL Hughes, CM Heuer, CM Heuer, CW Dunn, D Arendt, DA Dorsett, DA Dorsett, David K. Jacobs, DK Jacobs, DK Jacobs, DR Angelini, DR Angelini, DR Maddison, DW Golding, DW Stock, E Abouheif, EC Seaver, EC Seaver, F Ronquist, G Aspöck, G Balavoine, G Campbell, G Giribet, G Mardon, G Panganiban, G Panganiban, G Panganiban, G Scholtz, G Scholtz, G Scholtz, GA Wray, GF Striedter, GO Pflugfelder, GP Wagner, J Felsenstein, J Mallatt, J Mallatt, J Paps, J Paps, JD Thompson, JE Smith, JH Imai, JI Hamaker, JI Pueyo, JJ Gibson-Brown, Jonathan E. Valencia, K Bell, KJ Sepp, KL Hammond, KL Hammond, KS Pappu, L Maves, L Orrhage, L Orrhage, M Kulakova, M Qiu, M Schoppmeier, MJ Bastiani, MJ Telford, N Dray, N Gorfinkiel, N Shubin, N Shubin, N-M Prpic, N-M Prpic, N-M Prpic, N-M Prpic, NJ Strausfeld, NT Takaesu, P Dollé, R Abascal, R Desper, R Janssen, R Janssen, R Kirsch, R Tomer, RF Robledo, RJ Davis, S Candiani, S Guindon, S Nissim, SB Carroll, SF Altschul, SM Cohen, SM Cohen, SM Farris, SQ Irvine, SQ Irvine, SR Martini, T Bartolomaeus, T Kojima, TA Heanue, TA Williams, TH Bullock, W Arthur, W Sewell, W Westheide, WJ Brook, WJ Dickinson, X Yang, Y Boilly-Marer, Y Inoue, Y Inoue, Y Kida, Z Kozmik, Z Kozmik   +125 more
core   +4 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Finding New Cell Wall Regulatory Genes in Populus trichocarpa Using Multiple Lines of Evidence. [PDF]

, 2019
Understanding the regulatory network controlling cell wall biosynthesis is of great interest in Populus trichocarpa, both because of its status as a model woody perennial and its importance for lignocellulosic products.
Chen, Jin-Gui, DiFazio, Stephen, Dixon, Richard A, Furches, Anna, Gazolla, Joao Gabriel Felipe Machado, Jacobson, Daniel, Jones, Piet, Joubert, Wayne, Kainer, David, Large, Annabel, Macaya-Sanz, David, Martin, Madhavi Z, Ranjan, Priya, Rao, Xiaolan, Romero, Jonathon, Schmutz, Jeremy, Shah, Manesh, Sreedasyam, Avinash, Streich, Jared, Tschaplinski, Timothy J, Tuskan, Gerald A, Walker, Angelica M, Weighill, Deborah, Zhao, Nan   +23 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

NK2 homeobox gene cluster: Functions and roles in human diseases

Genes and Diseases, 2023
NK2 genes (NKX2 gene cluster in humans) encode for homeodomain-containing transcription factors that are conserved along the phylogeny. According to the most detailed classifications, vertebrate NKX2 genes are classified into two distinct families, NK2.1
Catia Mio, Federica Baldan, Giuseppe Damante   +2 more
doaj   +1 more source

Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis [PDF]

, 2019
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Xu, X., Li, G., Li, C., Zhang, J., Wang, Q., Simmons, D. K., Chen, X., Wijesena, N., Zhu, W., Wang, Z.,
Aluru, Neelakanteswar, Chen, Xuepeng, Ci, Weimin, Ju, Bao, Li, Congru, Li, Guoqiang, Liu, Jiang, Lu, Xuemei, Martindale, Mark Q., Oliveri, Paola, Simmons, David K., Wang, Qian-fei, Wang, Qiang, Wang, Zhanyang, Wang, Zhenhua, Wijesena, Naveen, Xu, Xiaocui, Yu, Daqi, Zhang, Jing, Zhang, Yong E., Zhu, Wei   +20 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Aspergillus flavus Homeobox Gene, hbx1, Is Required for Development and Aflatoxin Production

Toxins, 2017
Homeobox proteins, a class of well conserved transcription factors, regulate the expression of targeted genes, especially those involved in development.
Jeffrey W. Cary, Pamela Harris-Coward, Leslie Scharfenstein, Brian M. Mack, Perng-Kuang Chang, Qijian Wei, Matthew Lebar, Carol Carter-Wientjes, Rajtilak Majumdar, Chandrani Mitra, Sourav Banerjee, Anindya Chanda   +11 more
doaj   +1 more source

Spatial mechanisms of gene regulation in metazoan embryos [PDF]

, 1991
The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development.
Davidson, Eric H.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source