Results 51 to 60 of about 119,960 (296)

Spatial mechanisms of gene regulation in metazoan embryos [PDF]

, 1991
The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development.
Davidson, Eric H.
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

On a model mechanism for the spatial patterning of teeth primordia in the Alligator [PDF]

, 1996
We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role ...
Cruywagen, G. C., Ferguson, M. W. J., Kulesa, P. M., Lubkin, S. R., Maini, P. K., Murray, J. D., Sneyd, J. S.   +6 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Aspergillus flavus Homeobox Gene, hbx1, Is Required for Development and Aflatoxin Production

Toxins, 2017
Homeobox proteins, a class of well conserved transcription factors, regulate the expression of targeted genes, especially those involved in development.
Jeffrey W. Cary, Pamela Harris-Coward, Leslie Scharfenstein, Brian M. Mack, Perng-Kuang Chang, Qijian Wei, Matthew Lebar, Carol Carter-Wientjes, Rajtilak Majumdar, Chandrani Mitra, Sourav Banerjee, Anindya Chanda   +11 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

NK2 homeobox gene cluster: Functions and roles in human diseases

Genes and Diseases, 2023
NK2 genes (NKX2 gene cluster in humans) encode for homeodomain-containing transcription factors that are conserved along the phylogeny. According to the most detailed classifications, vertebrate NKX2 genes are classified into two distinct families, NK2.1
Catia Mio, Federica Baldan, Giuseppe Damante   +2 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Characterization of Rice Homeobox Genes, OsHOX22 and OsHOX24, and Over-expression of OsHOX24 in Transgenic Arabidopsis Suggest their Role in Abiotic Stress Response

Frontiers in Plant Science, 2016
Homeobox transcription factors are well known regulators of plant growth and development. In this study, we carried out functional analysis of two candidate stress-responsive HD-ZIP I class homeobox genes from rice, OsHOX22 and OsHOX24.
Annapurna eBhattacharjee, Jitendra Paul Khurana, Mukesh eJain, Mukesh eJain   +3 more
doaj   +1 more source

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria [PDF]

, 2010
The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build ...
A Abzhanov, A Caracciolo, A Hejnol, A Hidalgo, A Horner, A Minelli, A Minelli, A Saudemont, A Schmidt-Rhaesa, A Wallberg, AD Chipman, AS Denes, B Hausdorf, B Mittmann, B Prud’homme, B Rhode, C Nielsen, Christopher J. Winchell, CJ Tabin, CJ Winchell, CL Hughes, CM Heuer, CM Heuer, CW Dunn, D Arendt, DA Dorsett, DA Dorsett, David K. Jacobs, DK Jacobs, DK Jacobs, DR Angelini, DR Angelini, DR Maddison, DW Golding, DW Stock, E Abouheif, EC Seaver, EC Seaver, F Ronquist, G Aspöck, G Balavoine, G Campbell, G Giribet, G Mardon, G Panganiban, G Panganiban, G Panganiban, G Scholtz, G Scholtz, G Scholtz, GA Wray, GF Striedter, GO Pflugfelder, GP Wagner, J Felsenstein, J Mallatt, J Mallatt, J Paps, J Paps, JD Thompson, JE Smith, JH Imai, JI Hamaker, JI Pueyo, JJ Gibson-Brown, Jonathan E. Valencia, K Bell, KJ Sepp, KL Hammond, KL Hammond, KS Pappu, L Maves, L Orrhage, L Orrhage, M Kulakova, M Qiu, M Schoppmeier, MJ Bastiani, MJ Telford, N Dray, N Gorfinkiel, N Shubin, N Shubin, N-M Prpic, N-M Prpic, N-M Prpic, N-M Prpic, NJ Strausfeld, NT Takaesu, P Dollé, R Abascal, R Desper, R Janssen, R Janssen, R Kirsch, R Tomer, RF Robledo, RJ Davis, S Candiani, S Guindon, S Nissim, SB Carroll, SF Altschul, SM Cohen, SM Cohen, SM Farris, SQ Irvine, SQ Irvine, SR Martini, T Bartolomaeus, T Kojima, TA Heanue, TA Williams, TH Bullock, W Arthur, W Sewell, W Westheide, WJ Brook, WJ Dickinson, X Yang, Y Boilly-Marer, Y Inoue, Y Inoue, Y Kida, Z Kozmik, Z Kozmik   +125 more
core   +4 more sources