Evolution of homeobox genes [PDF]
, 2020 Many homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and have diversified into 11 gene classes and over 100 gene families in animal evolution, and 10 to
Peter W H Holland
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Presence of eight distinct homeobox-containing genes in cnidarians [PDF]
, 1993 Using the polymerase chain reaction, we identified four different homeobox-containing genes in Hydra magnipapillata. Three of them, cnox1-Hm, cnox2-Hm and cnox4-Hm, were equivalent to homeobox genes that had already been identified in other species of ...
Toshitaka Fujisawa +7 more
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Autism-associated SNPs in the clock genes _npas2_, _per1_ and the homeobox gene _en2_ alter DNA sequences that show characteristics of microRNA genes. [PDF]
, 2008 Intronic single nucleotide polymorphisms (SNPs) in the clock genes _npas2_ and _per1_ and the homeobox gene _en2_ are reported to be associated with autism.
Michael J. Owen +3 more
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Timing the generation of distinct retinal cells by homeobox proteins.
PLoS Biology, 2006 The reason why different types of vertebrate nerve cells are generated in a particular sequence is still poorly understood. In the vertebrate retina, homeobox genes play a crucial role in establishing different cell identities.
Sarah Decembrini +4 more
doaj +1 more source
Protein evolution of ANTP and PRD homeobox genes
BMC Evolutionary Biology, 2008 Background Although homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes.
Holland Peter WH +3 more
doaj +1 more source
Optimal activation of an endogenous gene by HOX11 requires the NH 2- terminal 50 amine acids [PDF]
, 1998 The HOX11 homeobox gene was first identified through studies of the t(7;10) and t(10;14) chromosomal translocations of acute T-cell leukemia. In addition, analysis of Hox11(-/-) mice has demonstrated a critical role for this gene in murine spleen ...
Masson, N., Greene, W.K., Rabbitts, T.H.
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Evaluating the Level of Homeobox B8 and its Association with Cell Lung Cancer Proliferation Downregulation: A Systematic Review and Meta-analysis [PDF]
International Journal of Scientific Research in Dental and Medical SciencesBackground and aim: Homeobox family genes have been identified as cancer growth regulators. There is no meta-analysis or comprehensive study on the activity of Homeobox B8 (HOXB8) in lung cancer.
Maryam Hassanpour Amnieh +3 more
doaj +1 more source
Identification of Methylated Genes Associated with Aggressive Clinicopathological Features in Mantle Cell Lymphoma [PDF]
, 2011 Background: Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. The contribution of DNA methylation to MCL lymphomagenesis is not well known.
Campo Elías +37 more
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Genome-Wide Analysis of the WOX Gene Family and Function Exploration of GmWOX18 in Soybean
Plants, 2019 WUSCHEL-related homeobox (WOX) is a family of transcription factors that are unique to plants and is characterized by the presence of a homeodomain. The WOX transcription factor plays an important role in regulating plant growth and development and the ...
Qingnan Hao +4 more
doaj +1 more source
Identification of downstream target genes of the t-cell oncoprotein HOX11 by global gene expression profiling [PDF]
, 2004 HOX11 is a homeodomain transcription factor that has been implicated in leukaemic transformation associated with T-cell acute lymphoblastic leukaemia (T-ALL).
Dixon, Darcelle Natalie
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