Results 1 to 10 of about 3,039,660 (257)

Adaptive Laboratory Evolution Reveals the Selenium Efflux Process To Improve Selenium Tolerance Mediated by the Membrane Sulfite Pump in Saccharomyces cerevisiae

open access: yesMicrobiology Spectrum, 2023
Selenium (Se) is a micronutrient in most eukaryotes, and Se-enriched yeast is the most common selenium supplement. However, selenium metabolism and transport in yeast have remained unclear, greatly hindering the application of this element.
Ao Gong   +4 more
doaj   +1 more source

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway

open access: yesCell Death Discovery, 2022
Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear.
Shang-Ze Li   +12 more
doaj   +1 more source

Osmotic Homeostasis [PDF]

open access: yesClinical Journal of the American Society of Nephrology, 2015
Alterations in water homeostasis can disturb cell size and function. Although most cells can internally regulate cell volume in response to osmolar stress, neurons are particularly at risk given a combination of complex cell function and space restriction within the calvarium. Thus, regulating water balance is fundamental to survival.
John, Danziger, Mark L, Zeidel
openaire   +2 more sources

Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome

open access: yesCell & Bioscience, 2020
Background Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.
Yibin Cheng   +13 more
doaj   +1 more source

SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury

open access: yesScientific Reports, 2021
In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is ...
Jin-Ze Tian   +7 more
doaj   +1 more source

Copper homeostasis and cuproptosis in health and disease

open access: yesSignal Transduction and Targeted Therapy, 2022
As an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis ...
Liyun Chen, J. Min, Fudi Wang
semanticscholar   +1 more source

Setd4 controlled quiescent c-Kit+ cells contribute to cardiac neovascularization of capillaries beyond activation

open access: yesScientific Reports, 2021
Blood vessels in the adult mammal exist in a highly organized and stable state. In the ischemic heart, limited expansion capacity of the myocardial vascular bed cannot satisfy demands for oxygen supply and the myocardium eventually undergoes irreversible
Sheng Xing   +7 more
doaj   +1 more source

Homeostasis as the Mechanism of Evolution. [PDF]

open access: yes, 2015
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
Torday, John S
core   +5 more sources

Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis

open access: yesInternational Journal of Molecular Sciences, 2022
Regulated cell death (RCD) has a significant impact on development, tissue homeostasis, and the occurrence of various diseases. Among different forms of RCD, ferroptosis is considered as a type of reactive oxygen species (ROS)-dependent regulated ...
L. Rochette   +5 more
semanticscholar   +1 more source

The pH-Responsive Transcription Factors YlRim101 and Mhy1 Regulate Alkaline pH-Induced Filamentation in the Dimorphic Yeast Yarrowia lipolytica

open access: yesmSphere, 2021
The regulatory mechanism that governs pH-regulated filamentation is not clear in dimorphic fungi except in Candida albicansYarrowia lipolyticaC ...
Tao Shu   +4 more
doaj   +1 more source

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