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Harnessing Hormonal Signaling for Cardioprotection
Science of Aging Knowledge Environment, 2005Cardiovascular disease is the leading cause of death in women in the Western world and is predominant among the elderly. A large body of evidence suggests that hormonal signaling plays a critical role in the regulation of cardioprotective mechanisms, as premenopausal women are at significantly lower risk of heart disease compared with men, but the risk
Victoria L, Ballard, Jay M, Edelberg
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Hormone evolution: The key to signalling
Nature, 2003The similarity of hydrophobic hormones in plants and animals suggests that once you make a good key, with occasional filing it can be used in many different developmental locks.
Tetsuo, Kushiro +2 more
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Plant peptide hormone signalling
Essays in Biochemistry, 2015The ligand–receptor-based cell-to-cell communication system is one of the most important molecular bases for the establishment of complex multicellular organisms. Plants have evolved highly complex intercellular communication systems. Historical studies have identified several molecules, designated phytohormones, that function in these processes ...
Ayane, Motomitsu +2 more
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Thyroid hormone signaling in the hypothalamus
Current Opinion in Endocrinology, Diabetes & Obesity, 2008Proper thyroid hormone signaling is essential for brain development and adult brain function. Signaling can be disrupted at many levels due to altered thyroid hormone secretion, conversion or thyroid hormone receptor binding.Mutated genes involved in thyroid hormone signaling in patients and animal models have increased the understanding of the (patho-)
Alkemade, Anneke +2 more
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Simple hormones but complex signalling
Current Opinion in Plant Biology, 2003It has not been easy to make sense of the pleiotropic effects of plant hormones, especially of auxins; but now, it has become possible to study these effects within the framework of what we know about signal transduction in general. Changes in local auxin concentrations, perhaps even actively maintained auxin gradients, signal to networks of ...
Vogler H, Kuhlemeier C
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2016
Failure to communicate is rarely a good thing. At a personal level, it can ruin a relationship; at a national level, it can lead to war and strife. The same is true in our own bodies. Diseases like diabetes are the direct result of failure to communicate. Our bodies are very big, and our cells are very small, so they need to talk to one another to make
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Failure to communicate is rarely a good thing. At a personal level, it can ruin a relationship; at a national level, it can lead to war and strife. The same is true in our own bodies. Diseases like diabetes are the direct result of failure to communicate. Our bodies are very big, and our cells are very small, so they need to talk to one another to make
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Roles of Hormones in Taste Signaling
2010Proper nutrition, avoidance of ingesting substances that are harmful to the whole organism, and maintenance of energy homeostasis are crucial for living organisms. Additionally, mammals possess a sophisticated system to control the types and content of food that we swallow.
Yu-Kyong, Shin, Josephine M, Egan
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GENETIC ANALYSIS OF HORMONE SIGNALING
Annual Review of Plant Physiology and Plant Molecular Biology, 1999▪ Abstract Phytohormones influence many diverse developmental processes ranging from seed germination to root, shoot, and flower formation. Recently, mutational analysis using the model plant Arabidopsis thaliana has been instrumental in determining the individual components of specific hormone signal transduction pathways.
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The evolution of hormonal signalling systems
Comparative Biochemistry and Physiology Part A: Physiology, 19911. A comparative analysis was made of chemosignalling systems responsible for the action of hormones, hormone-like substances, pheromones, etc. in vertebrates--multicellular invertebrates--unicellular eukaryotes. Many common features revealed in structural-functional organization of the above systems give evidence of their evolutionary conservatism. 2.
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Regulators of growth hormone signaling
2000Growth hormone acts through binding to membrane receptors that belong to the cytokine receptor superfamily. Ligand binding induces receptor dimerization and activation of the receptor-associated kinase: JAK2; this results in phosphorylation of the kinase itself, of the receptor, and of many cellular proteins.
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