Results 141 to 150 of about 227,089 (238)

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Nutritional Immunity in Wound Infection: Unveiling the Role of Dietary Elements in Host-Pathogen Interaction. [PDF]

Food Sci Nutr
Chen C, Hu X, He D, He X, Shen L.
europepmc   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Editorial: Herpesvirus: transmission, pathogenesis, host-pathogen interaction, and treatment. [PDF]

Front Microbiol
Yadavalli T, Awasthi S, Li J.
europepmc   +1 more source

Editorial: Bacillus spp. - Transmission, pathogenesis, host-pathogen interaction, prevention and treatment. [PDF]

Front Microbiol, 2023
Baindara P, Aslam B.
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Genetic strategies for avian influenza resilience in poultry: from host-pathogen interaction studies to precision breeding. [PDF]

Funct Integr Genomics
Majumdar D, Hann E, Short KR, Schat KA, Challagulla A.   +4 more
europepmc   +1 more source

Editorial: Aeromonas spp.-transmission, pathogenesis, host-pathogen interaction, prevention and treatment. [PDF]

Front Microbiol, 2023
Pang M.
europepmc   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

CRISPR <i>cas7</i> influences the host-pathogen interaction of <i>Porphyromonas gingivalis</i>. [PDF]

J Oral Microbiol
de Mello Fiallos N, Irfan M, Solbiati J, R Walker A, Frias-Lopez J, Gibson FC.   +5 more
europepmc   +1 more source