Results 21 to 30 of about 713,544 (377)

High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages

open access: yesFEBS Open Bio, 2023
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis.
Beren Aylan   +3 more
doaj   +1 more source

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

open access: yesNature Communications, 2021
Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination ...
Pierre Santucci   +5 more
doaj   +1 more source

Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice

open access: yesMicrobiology Spectrum, 2021
Inflammation plays a crucial role in the control of Mycobacterium tuberculosis infection. In this study, we demonstrate that an inflammatory pulmonary environment at the time of infection mediated by lipopolysaccharide treatment in mice confers enhanced ...
Tucker J. Piergallini   +5 more
doaj   +1 more source

Genotypic virulence profiles and associations in Salmonella isolated from meat samples in wet markets and abattoirs of Metro Manila, Philippines

open access: yesBMC Microbiology, 2022
Background Salmonella are pathogenic foodborne bacteria with complex pathogenicity from numerous virulence genes housed in Salmonella pathogenicity islands (SPIs), plasmids, and other gene cassettes.
Rance Derrick N. Pavon   +4 more
doaj   +1 more source

A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

open access: yesBMC Biology, 2021
Background Biomarker discovery remains a major challenge for predictive medicine, in particular, in the context of chronic diseases. This is true for the widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism in metazoans ...
Céline Dard   +9 more
doaj   +1 more source

Two-dimensional three-body quadrupole-quadrupole interactions [PDF]

open access: yes, 2021
Similar to interactions between dipoles, or van der Waals interactions, quadrupole-quadrupole interactions are interactions between quadrupoles. In this article, we study the quadrupole interactions between highly excited atoms or Rydberg atoms. In addition, unlike many other calculations, in which the primary focus was on the one-dimensional two-body ...
arxiv   +1 more source

Genotypic detection of β-lactamase-producing Escherichia coli isolates obtained from Seven Crater Lakes of San Pablo, Laguna, Philippines

open access: yesJournal of Water and Health, 2023
The extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is becoming a global public health concern. More comprehensive surveillance of β-lactam resistance in E.
Diana Rose D. Mamawal   +6 more
doaj   +1 more source

DeepSI: Interactive Deep Learning for Semantic Interaction [PDF]

open access: yesIUI '21: 26th International Conference on Intelligent User Interfaces, College Station, TX, USA, April 2021, 2023
In this paper, we design novel interactive deep learning methods to improve semantic interactions in visual analytics applications. The ability of semantic interaction to infer analysts' precise intents during sensemaking is dependent on the quality of the underlying data representation.
arxiv   +1 more source

Zebrafish Embryo Infection Model to Investigate Pseudomonas aeruginosa Interaction With Innate Immunity and Validate New Therapeutics

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
The opportunistic human pathogen Pseudomonas aeruginosa is responsible for a variety of acute infections and is a major cause of mortality in chronically infected patients with cystic fibrosis (CF). Considering the intrinsic and acquired resistance of P.
Stéphane Pont   +3 more
doaj   +1 more source

Transferable Interactiveness Knowledge for Human-Object Interaction Detection [PDF]

open access: yesIEEE Transactions on Pattern Analysis and Machine Intelligence, 2021, 2021
Human-Object Interaction (HOI) detection is an important problem to understand how humans interact with objects. In this paper, we explore interactiveness knowledge which indicates whether a human and an object interact with each other or not. We found that interactiveness knowledge can be learned across HOI datasets and bridge the gap between diverse ...
arxiv   +1 more source

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