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Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis.
Beren Aylan+3 more
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Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination ...
Pierre Santucci+5 more
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Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice
Inflammation plays a crucial role in the control of Mycobacterium tuberculosis infection. In this study, we demonstrate that an inflammatory pulmonary environment at the time of infection mediated by lipopolysaccharide treatment in mice confers enhanced ...
Tucker J. Piergallini+5 more
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Background Salmonella are pathogenic foodborne bacteria with complex pathogenicity from numerous virulence genes housed in Salmonella pathogenicity islands (SPIs), plasmids, and other gene cassettes.
Rance Derrick N. Pavon+4 more
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Background Biomarker discovery remains a major challenge for predictive medicine, in particular, in the context of chronic diseases. This is true for the widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism in metazoans ...
Céline Dard+9 more
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Two-dimensional three-body quadrupole-quadrupole interactions [PDF]
Similar to interactions between dipoles, or van der Waals interactions, quadrupole-quadrupole interactions are interactions between quadrupoles. In this article, we study the quadrupole interactions between highly excited atoms or Rydberg atoms. In addition, unlike many other calculations, in which the primary focus was on the one-dimensional two-body ...
arxiv +1 more source
The extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is becoming a global public health concern. More comprehensive surveillance of β-lactam resistance in E.
Diana Rose D. Mamawal+6 more
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DeepSI: Interactive Deep Learning for Semantic Interaction [PDF]
In this paper, we design novel interactive deep learning methods to improve semantic interactions in visual analytics applications. The ability of semantic interaction to infer analysts' precise intents during sensemaking is dependent on the quality of the underlying data representation.
arxiv +1 more source
The opportunistic human pathogen Pseudomonas aeruginosa is responsible for a variety of acute infections and is a major cause of mortality in chronically infected patients with cystic fibrosis (CF). Considering the intrinsic and acquired resistance of P.
Stéphane Pont+3 more
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Transferable Interactiveness Knowledge for Human-Object Interaction Detection [PDF]
Human-Object Interaction (HOI) detection is an important problem to understand how humans interact with objects. In this paper, we explore interactiveness knowledge which indicates whether a human and an object interact with each other or not. We found that interactiveness knowledge can be learned across HOI datasets and bridge the gap between diverse ...
arxiv +1 more source