Results 21 to 30 of about 803,197 (352)

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Nature Communications, 2021
Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination ...
Pierre Santucci, Daniel J. Greenwood, Antony Fearns, Kai Chen, Haibo Jiang, Maximiliano G. Gutierrez   +5 more
doaj   +1 more source

The Ubiquitination System within Bacterial Host–Pathogen Interactions

Microorganisms, 2021
Ubiquitination of proteins, like phosphorylation and acetylation, is an important regulatory aspect influencing numerous and various cell processes, such as immune response signaling and autophagy.
Vera Vozandychova, Pavla Stojkova, K. Hercík, P. Rehulka, J. Stulík   +4 more
semanticscholar   +1 more source

In Vitro Models for Studying Respiratory Host–Pathogen Interactions

Advances in Biology, 2021
Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus‐2 pandemic, are of high and prevalent socio‐economic importance.
Sarah L Barron, J. Saez, R. Owens
semanticscholar   +1 more source

Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice

Microbiology Spectrum, 2021
Inflammation plays a crucial role in the control of Mycobacterium tuberculosis infection. In this study, we demonstrate that an inflammatory pulmonary environment at the time of infection mediated by lipopolysaccharide treatment in mice confers enhanced ...
Tucker J. Piergallini, Julia M. Scordo, Paula A. Pino, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner   +5 more
doaj   +1 more source

Cadherin‐mediated host–pathogen interactions

Cellular Microbiology, 2021
Cell adhesion molecules mediate cell‐to‐cell and cell‐to‐matrix adhesions and play an immense role in a myriad of physiological processes during the growth and development of a multicellular organism.
S. Dash, Kheerthana Duraivelan, D. Samanta   +2 more
semanticscholar   +1 more source

Genotypic virulence profiles and associations in Salmonella isolated from meat samples in wet markets and abattoirs of Metro Manila, Philippines

BMC Microbiology, 2022
Background Salmonella are pathogenic foodborne bacteria with complex pathogenicity from numerous virulence genes housed in Salmonella pathogenicity islands (SPIs), plasmids, and other gene cassettes.
Rance Derrick N. Pavon, Paolo D. G. Mendoza, Camille Andrea R. Flores, Alyzza Marie B. Calayag, Windell L. Rivera   +4 more
doaj   +1 more source

Induced pluripotent stem cell line (PEIi003-A) derived from an apparently healthy male individual

Stem Cell Research, 2020
Induced pluripotent stem cells (iPSCs) are a useful tool to investigate pathomechanistic and cellular processes due to their differentiation potential into different somatic cell types in vitro.
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Doris Steinemann, Gudrun Göhring, Renate König   +7 more
doaj   +1 more source

A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

BMC Biology, 2021
Background Biomarker discovery remains a major challenge for predictive medicine, in particular, in the context of chronic diseases. This is true for the widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism in metazoans ...
Céline Dard, Christopher Swale, Marie-Pierre Brenier-Pinchart, Dayana C. Farhat, Valeria Bellini, Marie Gladys Robert, Dominique Cannella, Hervé Pelloux, Isabelle Tardieux, Mohamed-Ali Hakimi   +9 more
doaj   +1 more source

The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions

Genes & Development, 2020
In this review, Fehr et al. summarize the current understanding of the mechanisms by which PARPs promote or suppress proinflammatory activation of macrophages, and also discuss various other roles PARPs play in virus infections.
Anthony R. Fehr, Sasha A. Singh, Catherine M. Kerr, S. Mukai, Hideyuki Higashi, M. Aikawa   +5 more
semanticscholar   +1 more source

Genotypic detection of β-lactamase-producing Escherichia coli isolates obtained from Seven Crater Lakes of San Pablo, Laguna, Philippines

Journal of Water and Health, 2023
The extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is becoming a global public health concern. More comprehensive surveillance of β-lactam resistance in E.
Diana Rose D. Mamawal, Jonah David V. Calayo, Kherson P. Gandola, Mae Ashley G. Nacario, Mark Raymond A. Vejano, Laurice Beatrice Raphaelle O. dela Peña, Windell L. Rivera   +6 more
doaj   +1 more source