Results 21 to 30 of about 240,356 (162)

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi–Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)

Stem Cell Research, 2020
Aicardi-Goutières syndrome (AGS) is a hereditary early onset encephalopathy. AGS patients display variable clinical manifestations including intracranial calcification, cerebral atrophy, white matter abnormalities and characteristic leukocytosis as well ...
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Lena Wendeburg, Doris Steinemann, Christiane Elpers, Frank Rutsch, Renate König   +9 more
doaj   +1 more source

The roles of GpsB and DivIVA in Staphylococcus aureus growth and division

Frontiers in Microbiology, 2023
The spheroid bacterium Staphylococcus aureus is often used as a model of morphogenesis due to its apparently simple cell cycle. S. aureus has many cell division proteins that are conserved across bacteria alluding to common functions.
Joshua A. F. Sutton, Joshua A. F. Sutton, Mark Cooke, Mariana Tinajero-Trejo, Mariana Tinajero-Trejo, Katarzyna Wacnik, Katarzyna Wacnik, Bartłomiej Salamaga, Bartłomiej Salamaga, Callum Portman-Ross, Callum Portman-Ross, Victoria A. Lund, Victoria A. Lund, Jamie K. Hobbs, Jamie K. Hobbs, Simon J. Foster, Simon J. Foster   +16 more
doaj   +1 more source

A new tractable method for generating human alveolar macrophage-like cells in vitro to study lung inflammatory processes and diseases

mBio, 2023
Alveolar macrophages (AMs) are unique lung resident cells that contact airborne pathogens and environmental particulates. The contribution of human AMs (HAMs) to pulmonary diseases remains poorly understood due to the difficulty in accessing them from ...
Susanta Pahari, Eusondia Arnett, Jan Simper, Abul Azad, Israel Guerrero-Arguero, Chengjin Ye, Hao Zhang, Hong Cai, Yufeng Wang, Zhao Lai, Natalie Jarvis, Miranda Lumbreras, Diego Jose Maselli, Jay Peters, Jordi B. Torrelles, Luis Martinez-Sobrido, Larry S. Schlesinger   +16 more
doaj   +1 more source

Tuberculosis in an Aging World

Pathogens, 2022
Tuberculosis (TB) is one of the leading causes of death due to its being an infectious disease, caused by the airborne pathogen Mycobacterium tuberculosis (M.tb).
Angélica M. Olmo-Fontánez, Joanne Turner   +1 more
doaj   +1 more source

Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy

Frontiers in Immunology
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments.
Alla Bulashevska, Zsófia Nacsa, Franziska Lang, Markus Braun, Martin Machyna, Mustafa Diken, Liam Childs, Renate König   +7 more
doaj   +1 more source

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

Nature Communications, 2018
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 ...
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König   +14 more
doaj   +1 more source

Phosphoinositides and host–pathogen interactions [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Phosphoinositides control key cellular processes including vesicular trafficking and actin polymerization. Intracellular bacterial pathogens manipulate phosphoinositide metabolism in order to promote their uptake by target cells and to direct in some cases the biogenesis of their replication compartments.
Pizarro-Cerdá, Javier, Kühbacher, Andreas, Cossart, Pascale   +2 more
openaire   +3 more sources

Manipulation of Autophagy and Apoptosis Facilitates Intracellular Survival of Staphylococcus aureus in Human Neutrophils

Frontiers in Immunology, 2020
Polymorphonuclear neutrophils (PMN) are critical for first line innate immune defence against Staphylococcus aureus. Mature circulating PMN maintain a short half-life ending in constitutive apoptotic cell death.
Michelle E. Mulcahy, Eóin C. O’Brien, Kate M. O’Keeffe, Emilio G. Vozza, Neal Leddy, Rachel M. McLoughlin   +5 more
doaj   +1 more source

Role of PQBP1 in Pathogen Recognition—Impact on Innate Immunity

Viruses
The intrinsically disordered polyglutamine-binding protein 1 (PQBP1) has been linked to various cellular processes including transcription, alternative splicing, translation and innate immunity.
Lukas Wiench, Domenico Rizzo, Zora Sinay, Zsófia Nacsa, Nina V. Fuchs, Renate König   +5 more
doaj   +1 more source

Molecular surveillance of Cryptosporidium spp. for microbial source tracking of fecal contamination in Laguna Lake, Philippines

Journal of Water and Health, 2021
Water quality deterioration in source waters poses increased health, environmental, and economic risks. Here, we genotyped Cryptosporidium spp. obtained from water samples of Laguna Lake, Philippines, and its tributaries for the purpose of source ...
Laurice Beatrice Raphaelle O. dela Peña, Mark Raymond A. Vejano, Windell L. Rivera   +2 more
doaj   +1 more source