Results 31 to 40 of about 240,356 (162)

Human Coronavirus: Host-Pathogen Interaction [PDF]

Annual Review of Microbiology, 2019
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV).
To Sing, Fung, Ding Xiang, Liu
openaire   +2 more sources

In Silico Approaches for the Identification of Aptamer Binding Interactions to Leptospira spp. Cell Surface Proteins

Tropical Medicine and Infectious Disease, 2023
Aptamers are nucleic acids that can bind with high affinity and specificity to a range of target molecules. However, their functionality relies on their secondary and tertiary structures such that the combination of nucleotides determines their three ...
Chembie A. Almazar, Marjo V. Mendoza, Windell L. Rivera   +2 more
doaj   +1 more source

Host-Pathogen Interactions of Retroviruses [PDF]

Molecular Biology International, 2012
Retroviruses, such as HIV-1, are enveloped RNA viruses that use the enzyme reverse transcriptase (RT) to make a DNA copy of their RNA genome during replication in the host cell. The retrovirus life cycle is generally divided into two distinct phases: the early and late phase.
Waheed, Abdul A., Brass, Abraham L., Gummuluru, Suryaram, Tachedjian, Gilda   +3 more
openaire   +2 more sources

Host–Pathogen Interactions [PDF]

Clinical Therapeutics, 2019
Dean Southwood, Shoba Ranganathan
  +5 more sources

Characterising within-hospitalSARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves

Nature Communications, 2022
SARS-CoV-2 has resulted in multiple outbreaks in hospitals, but identifying transmission events is challenging. Here, the authors combine whole genome sequencing and epidemiological data from the first two waves of the pandemic at a UK hospital trust and
Benjamin B. Lindsey, Ch. Julián Villabona-Arenas, Finlay Campbell, Alexander J. Keeley, Matthew D. Parker, Dhruv R. Shah, Helena Parsons, Peijun Zhang, Nishchay Kakkar, Marta Gallis, Benjamin H. Foulkes, Paige Wolverson, Stavroula F. Louka, Stella Christou, Amy State, Katie Johnson, Mohammad Raza, Sharon Hsu, Thibaut Jombart, Anne Cori, Sheffield COVID-19 Genomics Group, The COVID-19 Genomics UK (COG-UK) consortium, CMMID COVID-19 working group, Cariad M. Evans, David G. Partridge, Katherine E. Atkins, Stéphane Hué, Thushan I. de Silva   +27 more
doaj   +1 more source

Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV

Frontiers in Immunology, 2021
Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral ...
David Pires, Marta Calado, Tomás Velez, Manoj Mandal, Maria João Catalão, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet, José Miguel Azevedo-Pereira, Elsa Anes   +9 more
doaj   +1 more source

Cell-to-Cell Transmission of HIV-1 and HIV-2 from Infected Macrophages and Dendritic Cells to CD4+ T Lymphocytes

Viruses, 2023
Macrophages (Mø) and dendritic cells (DCs) are key players in human immunodeficiency virus (HIV) infection and pathogenesis. They are essential for the spread of HIV to CD4+ T lymphocytes (TCD4+) during acute infection.
Marta Calado, David Pires, Carolina Conceição, Rita Ferreira, Quirina Santos-Costa, Elsa Anes, José Miguel Azevedo-Pereira   +6 more
doaj   +1 more source

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

Viruses, 2020
Hepatitis B virus (HBV) chronic infection is a critical risk factor for hepatocellular carcinoma. The innate immune response to HBV infection is a matter of debate. In particular, viral escape mechanisms are poorly understood.
Lise Lauterbach-Rivière, Maïwenn Bergez, Saskia Mönch, Bingqian Qu, Maximilian Riess, Florian W. R. Vondran, Juliane Liese, Veit Hornung, Stephan Urban, Renate König   +9 more
doaj   +1 more source

Hippo signaling pathway regulates Ebola virus transcription and egress

Nature Communications
Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical regulators of EBOV transcription and egress.
Jingjing Liang, Marija A. Djurkovic, Carson G. Leavitt, Olena Shtanko, Ronald N. Harty   +4 more
doaj   +1 more source

A live attenuated NS1-deficient vaccine candidate for cattle-origin influenza A (H5N1) clade 2.3.4.4.b viruses

npj Vaccines
Avian Influenza viruses (AIVs) present a public health risk, especially with seasonal vaccines offering limited protection. AIV H5N1 clade 2.3.4.4b has caused a multi-state outbreaks in the United States (US) poultry and cattle since March 2024, raising ...
Ahmed Mostafa, Chengjin Ye, Ramya S. Barre, Vinay Shivanna, Reagan Meredith, Roy N. Platt, Ruby A. Escobedo, Mahmoud Bayoumi, Esteban M. Castro, Nathaniel Jackson, Anastasija Cupic, Aitor Nogales, Timothy J. C. Anderson, Adolfo García-Sastre, Luis Martinez-Sobrido   +14 more
doaj   +1 more source