Results 141 to 150 of about 2,543,243 (266)

SUMOylated DDX3 Promotes HBV Replication and Tumor Growth of Hepatocellular Carcinoma via TRIM28‐DDX3‐KLF4α Signaling Axis

Advanced Science, EarlyView.
TRIM28 binds to DDX3 protein to catalyze the SUMOylation of DDX3 (S‐DDX3), thus the S‐DDX3 involves in aberrant alternative splicing of KLF4 mRNA, and the splicing variant KLF4α‐mediated cell cycle and signal transduction, weakens tumor suppressor function of DDX3 protein, which promotes progression of HBV‐HCC.
Yanfang Yang, Ting Kong, Binghan Wang, Xiaoli Jin, Lan Huang, Nan Zhang, Siyu Tang, Samina Ejaz Syed, Shufang Liang   +8 more
wiley   +1 more source

Effects of gut microbiota and metabolites on the host defense peptide expression

Applied Microbiology and Biotechnology
The widespread use of antibiotics has led to the emergence of multidrug-resistant bacteria, which pose significant threats to animal health and food safety.
Yuanli Jin, Tao Gong, Xiaoxi Lu, Yizhen Wang, Yuanzhi Cheng   +4 more
doaj   +1 more source

Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants. [PDF]

J Microbiol Biotechnol, 2023
Kim J, Cho BH, Jang YS.
europepmc   +1 more source

A Citrulline‐Functionalized Patch Coordinates Macrophage NRF2 Signaling and Arginine Metabolism for Tendon‐to‐Bone Repair

Advanced Science, EarlyView.
A locally implanted patch combines citrulline‐functionalized carbon dots, a thioketal‐containing membrane coating from tendon‐derived stem cells, and aligned core–shell fibers. In macrophages, the patch reduces inflammatory markers and enhances antioxidant signaling through nuclear factor erythroid 2‐related factor 2 (NRF2); in rats and rabbits, it ...
Yuhao Yu, Wencai Liu, Xinyue Yang, Hanzhe Zhang, Hui Xu, Xin Wang, Weimin Lin, Xiping Jiang, Chenrui Yuan, Yifei Wang, Weilin Yu, Yamin Li, Wei Song, Yaohua He   +13 more
wiley   +1 more source

Discovery of Novel Thanatin-like Antimicrobial Peptides from Bean Bug Riptortus pedestris

Pharmaceutics
Background: Endogenous antimicrobial peptides (AMPs) are evolutionarily ancient molecular factors of innate immunity that play a key role in host defense.
Pavel V. Panteleev, Julia S. Teplovodskaya, Anastasia D. Utkina, Anastasia A. Smolina, Roman N. Kruglikov, Victoria N. Safronova, Ilia A. Bolosov, Olga V. Korobova, Alexander I. Borzilov, Tatiana V. Ovchinnikova   +9 more
doaj   +1 more source

Purification, Conformational Analysis and Cytotoxic Activities of Host-Defense Peptides from the Giant Gladiator Treefrog Boana boans (Hylidae: Hylinae). [PDF]

Antibiotics (Basel), 2023
Conlon JM, Guilhaudis L, Attoub S, Coquet L, Leprince J, Jouenne T, Mechkarska M.   +6 more
europepmc   +1 more source

Host defense peptides in fish: from the peculiar to the mainstream

, 2009
In this chapter, the authors explains genetic, structural and functional relatives of non-fish host defense peptides in fish, and they devote a portion of this discussion to each of these topics.
Patrzykat, A., Hancock, R. E. W.
core  

Host-defense peptides from skin secretions of the octoploid frogs Xenopus vestitus and Xenopus wittei (Pipidae): Insights into evolutionary relationships

, 2014
International audienceThe primary structures of host-defense peptides have proved useful in elucidating the evolution history of frogs. Peptidomic analysis was used to compare the diversity of host-defense peptides in norepinephrine-stimulated skin ...
Michalak, Katarzyna, Milena Mechkarska, Pawel Michalak, Hubert Vaudry, Jérôme Leprince, Coquet, Laurent, Conlon, J. Michael, J. Michael Conlon, Vaudry, Hubert, Jouenne, Thierry, Thierry Jouenne, Laurent Coquet, Mechkarska, Milena, Leprince, Jérôme, Michalak, Pawel, Katarzyna Michalak   +15 more
core   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Multifunctional host defense peptides [PDF]

The FEBS Journal, 2009
Pierre Nicolas, Yvonne Rosenstein
openaire   +1 more source