Results 151 to 160 of about 2,543,243 (266)

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Host defense peptides combined with MTA extract increase the repair in dental pulp cells: in vitro and ex vivo study. [PDF]

Sci Rep, 2023
Silva PAO, Martins DCM, de Castro Cantuária AP, de Andrade RV, Lacorte C, de Almeida JA, Aguiar LR, Corrêa JR, da Silva IGM, Franco OL, Rezende TMB.   +10 more
europepmc   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Host Defense Peptides at the Ocular Surface: Roles in Health and Major Diseases, and Therapeutic Potentials. [PDF]

Front Med (Lausanne), 2022
Ting DSJ, Mohammed I, Lakshminarayanan R, Beuerman RW, Dua HS.   +4 more
europepmc   +1 more source

Are Host Defense Peptides and Their Derivatives Ready to be Part of the Treatment of the Next Coronavirus Pandemic? [PDF]

Arch Immunol Ther Exp (Warsz), 2021
Rivas-Santiago B, Jacobo-Delgado Y, Rodriguez-Carlos A.   +2 more
europepmc   +1 more source

Host defense peptides as effector molecules of the innate immune response

, 2009
Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses.
Hirsch, Tobias (Prof. Dr. med.), Steinsträßer, Lars (Prof. Dr. med.), Jacobsen, Frank (Dr. med.), Kraneburg, Ursula M., Kesting, Marco, Steinau, Hans-Ulrich (Prof. Dr. med.), Benna, Sammy al-   +6 more
core   +1 more source

Mechanisms and Modifications of Naturally Occurring Host Defense Peptides for Anti-HIV Microbicide Development

, 2012
Despite advances in the treatment of HIV infection, heterosexual transmission of HIV remains high, and vaccines to prevent HIV acquisition have been unfruitful.

core  

Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages. [PDF]

J Innate Immun, 2022
Hansen FC, Nadeem A, Browning KL, Campana M, Schmidtchen A, van der Plas MJA.   +5 more
europepmc   +1 more source

Comparative Meta‐Analysis of Antimicrobial Peptides in Aquatic and Terrestrial Livestock Species

Animal Research and One Health, EarlyView.
A global meta‐analysis of 58 studies (926 effect sizes and 29 species across five taxa) revealed that dietary antimicrobial peptides generally improve growth performance, blood metabolites, and immune responses. The greatest benefits were observed in omnivorous livestock, such as pigs and chickens. Dose‐duration effects were evident. An optimal outcome
Lily Liu, Xu Luo, Qin Zhang, Jinhai Wang, Alan E. Wilson   +4 more
wiley   +1 more source