Results 181 to 190 of about 2,543,243 (266)

Delving Into the Origin of Destructive Inflammation in COVID-19: A Betrayal of Natural Host Defense Peptides? [PDF]

Front Immunol, 2020
Garcia-Fandino R, Piñeiro Á.
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides. [PDF]

Biomacromolecules
Biswas D, Benson S, Matunis A, Gebretsadik G, Wertz A, StPierre BJ, Schacht N, Yan Y, Gebremichael HY, Wong PK, Baughn AD, Medina SH.   +11 more
europepmc   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Dendrimer-Derived Mimics of Host Defense Peptides Selectively Disrupt Cancer Cell Membranes for Melanoma Therapy. [PDF]

Pharmaceutics
Qian Y, Yang D, Lin X, Shen C, Zhang J, Xu J, Zhao Y, Zhu L, Kong H, Zhang M, Zhu Y, Zhou C, He J.   +12 more
europepmc   +1 more source

Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in Streptococcus mitis-oralis. [PDF]

Antibiotics (Basel), 2021
Yeaman MR, Chan LC, Mishra NN, Bayer AS.
europepmc   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel. [PDF]

Nat Commun
Panteleev PV, Pichkur EB, Kruglikov RN, Paleskava A, Shulenina OV, Bolosov IA, Bogdanov IV, Safronova VN, Balandin SV, Marina VI, Kombarova TI, Korobova OV, Shamova OV, Myasnikov AG, Borzilov AI, Osterman IA, Sergiev PV, Bogdanov AA, Dontsova OA, Konevega AL, Ovchinnikova TV.   +20 more
europepmc   +1 more source

Strategies in Translating the Therapeutic Potentials of Host Defense Peptides. [PDF]

Front Immunol, 2020
Ting DSJ, Beuerman RW, Dua HS, Lakshminarayanan R, Mohammed I.   +4 more
europepmc   +1 more source