Results 211 to 220 of about 76,743 (235)
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Host defense peptides: front-line immunomodulators
Trends in Immunology, 2014Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now widely recognized for their multifunctional roles in both the innate and adaptive immune responses. Their diverse immunomodulatory capabilities include the modulation of pro- and anti-inflammatory responses, chemoattraction, enhancement of extracellular and ...
Sarah C, Mansour +2 more
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Host defense peptides: roles and applications.
Current protein & peptide science, 2005Editorial of special issue on Antimicrobial ...
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Antifungal Host Defense Peptides
2016Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago.
Karl Lohner, Regina Leber
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The Therapeutic Potential of Host-Defense Antimicrobial Peptides
Current Drug Targets, 2002Species across the evolutionary scale from insects to mammals deploy peptides to counter microbial invaders. Although, there are considerable differences in the primary and secondary structures of these peptides, they exert their antimicrobial activity by common mechanisms ie. by membrane permeabilization. Extensive structure-function studies have been
N, Sitaram, R, Nagaraj
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Natural History of Innate Host Defense Peptides
Probiotics and Antimicrobial Proteins, 2009Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features in their innate immune defense strategies, hereunder expression of host defense peptides (HDPs ...
A, Linde +7 more
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Potential Therapeutic Application of Host Defense Peptides
2009Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines.
Lijuan, Zhang, Timothy J, Falla
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Transcriptional Regulation of Antimicrobial Host Defense Peptides
Current Protein & Peptide Science, 2015Host defense peptides (HDPs) are of either myeloid or epithelial origin with antimicrobial and immunomodulatory functions. Due to HDP's ability to physically disrupt bacterial cell membranes and profoundly regulate host innate and adaptive immunity, microbial resistance to these peptides is rare.
Wentao, Lyu +3 more
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Functions of Antimicrobial Peptides in Host Defense and Immunity
Current Protein & Peptide Science, 2005Antimicrobial peptides (AMPs) are effector molecules of the innate immune system. AMPs have a broad antimicrobial spectrum and lyse microbial cells by interaction with biomembranes. Besides their direct antimicrobial function, they have multiple roles as mediators of inflammation with impact on epithelial and inflammatory cells influencing diverse ...
Christoph, Beisswenger, Robert, Bals
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Host defense peptides in crocodilians – A comprehensive review
PeptidesAmphibians and reptiles, like all animals, are prone to periodic infections. However, crocodilians stand out for their remarkable ability to remain generally healthy and infection-free despite frequent exposure to a wide variety of microorganisms in their habitats and often sustaining significant injuries.
Cordero Gil, Trinidad de Los Angeles +3 more
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Host Defense Peptides and the Eicosanoid Cascade
2016Host defense peptides (HDPs) and eicosanoids are two important families in host defense and inflammation. Most of the naturally occurring HDPs are cationic and amphipathic short polypeptides with typical length between 15 and 40 amino acid residues. HDPs not only possess potent antimicrobial activity against a variety of pathogens, they are also widely
Min Wan +2 more
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