Results 71 to 80 of about 2,543,243 (266)

Induction of Chicken Host Defense Peptides within Disease-Resistant and -Susceptible Lines. [PDF]

Genes (Basel), 2020
Host defense peptides (HDPs) are multifunctional immune molecules that respond to bacterial and viral pathogens. In the present study, bone marrow-derived cells (BMCs) and chicken embryonic fibroblasts (CEFs) were cultured from a Leghorn line (Ghs6) and ...
Jang HJ, Monson M, Kaiser M, Lamont SJ.
europepmc   +2 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics

Animal Nutrition, 2018
Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease prevention. However, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all ...
Kelsy Robinson, Xi Ma, Yulan Liu, Shiyan Qiao, Yongqing Hou, Guolong Zhang   +5 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?

Frontiers in Immunology, 2012
Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites and
Sophie eCotton, Sheila eDonnelly, Mark W. Robinson, Mark W. Robinson, John P. Dalton, Karine eThivierge, Karine eThivierge   +6 more
doaj   +1 more source

Expression and Function of Host Defense Peptides at Inflammation Sites. [PDF]

Int J Mol Sci, 2019
There is a growing interest in the complex role of host defense peptides (HDPs) in the pathophysiology of several immune-mediated inflammatory diseases. The physicochemical properties and selective interaction of HDPs with various receptors define their immunomodulatory effects. However, it is quite challenging to understand their function because some
Prasad SV, Fiedoruk K, Daniluk T, Piktel E, Bucki R.   +4 more
europepmc   +5 more sources

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Sap transporter mediated import and subsequent degradation of antimicrobial peptides in Haemophilus. [PDF]

PLoS Pathogens, 2011
Antimicrobial peptides (AMPs) contribute to host innate immune defense and are a critical component to control bacterial infection. Nontypeable Haemophilus influenzae (NTHI) is a commensal inhabitant of the human nasopharyngeal mucosa, yet is commonly ...
Catherine L Shelton, Forrest K Raffel, Wandy L Beatty, Sara M Johnson, Kevin M Mason   +4 more
doaj   +1 more source

Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons. [PDF]

, 2020
BackgroundHost defense peptides are a family of endogenous short peptides that are found in all living beings and play a critical role in innate immunity against infection.MethodsA nonsystematic review of host defense peptides was conducted with specific
Cederna, Paul S, Da Lio, Andrew L, Deming, Timothy J, DeLong, Michael R, Tandon, Vickram J, Michael R. DeLong, Andrew L. Da Lio, Paul S. Cederna, Timothy J. Deming, Vickram J. Tandon   +9 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source