Results 81 to 90 of about 2,543,243 (266)

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Molecules, 2018
Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike ...
Alicia Boto, Jose Manuel Pérez de la Lastra, Concepción C. González   +2 more
doaj   +1 more source

Dynamic Physicochemical Gradients for Tendon–Bone Regeneration

Advanced Functional Materials, EarlyView.
Dynamic physicochemical gradients offer a framework for reconnecting soft tendon and hard bone. This Review examines how hydration, transport, loading and degradation reshape these gradients during healing. Coordinating regional biological cues with progressive transfer of load from scaffold to tissue guides the design of interfaces that retain ...
Wanxue Wang, Minsheng Zhu, Junmiao Liu, Haowen Lu, Haoteng Wang, Yu Chen, Hua Liu, Zhengyu Xu, Zhiyong Sun, Huilin Yang, Yusen Qiao, Xia Zhao   +11 more
wiley   +1 more source

Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria

Frontiers in Immunology, 2017
Host-defense peptides play a fundamental role in the innate immune system by modulating inflammatory responses. Previously, it was shown that the thrombin derived host-defense peptide GKY25 inhibits LPS-induced responses of monocytes and macrophages in ...
Finja C. Hansen, Ann-Charlotte Strömdahl, Matthias Mörgelin, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Mariena J. A. van der Plas   +6 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

Host defense peptides at the crossroad of endothelial cell physiology : Insight into mechanistic and pharmacological implications

Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and ...
Yadav, Vikas,, Joshi, Hemant,, Yadav, Kiran,, Garg, Vivek Kumar,, Lund University., Sharma, Amarish Kumar,, Garg, Vivek Kumar, Yadav, Vikas, Sharma, Amarish Kumar, Joshi, Hemant, Yadav, Kiran   +10 more
core   +1 more source

Anti-antimicrobial Peptides FOLDING-MEDIATED HOST DEFENSE ANTAGONISTS:FOLDING-MEDIATED HOST DEFENSE ANTAGONISTS [PDF]

, 2013
Antimicrobial or host defense peptides are innate immune regulators found in all multicellular organisms. Many of them fold into membrane-bound α-helices and function by causing cell wall disruption in microorganisms.
Judge, Peter J., Su, Bo, Martyna, Glenn, Ryan, L, Su, B, Jenkinson, Howard F., Martyna, G, Lamarre, Baptiste, Ravi, Jascindra, Temple, A, Temple, Adam, Carr, Matthew, Carr, M, Crain, Jason, Jenkinson, HF, Cerasoli, E, Ryadnov, MG, Ravi, J, Judge, PJ, Ryan, Lloyd, Lamarre, B, Watts, A, Crain, J, Diu, Ting, Watts, Anthony, Diu, T, Cerasoli, Eleonora, Ryadnov, Maxim G.   +27 more
core   +1 more source

Multifunctional host defense peptides: antiparasitic activities [PDF]

The FEBS Journal, 2009
Whereas significant knowledge is accumulating on the antibacterial and antifungal properties of host defense peptides (HDPs) and their synthetic mimics, much less is known of their activities against parasites. A variety of in vitro and in vivo antiparasitic assays suggest that these notorious antimicrobial compounds could represent a powerful tool for
openaire   +2 more sources

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae

Pharmaceuticals, 2014
Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with varying degrees of antimicrobial activities and cytotoxicities to mammalian ...
J. Michael Conlon, Milena Mechkarska
doaj   +1 more source