Computational and Structural Biotechnology Journal, 2020 There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-
João Trigueiro-Louro +4 more
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The effect of environmental heterogeneity on RPW8-mediated resistance to powdery mildews in Arabidopsis thaliana [PDF]
, 2012 Background and Aims: The biotic and abiotic environment of interacting hosts and parasites may vary considerably over small spatial and temporal scales. It is essential to understand how different environments affect host disease resistance because this ...
Agrios +70 more
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Frontiers in Microbiology, 2019 The roles of signaling pathway genes related to the aflatoxin reduction trait in maize were studied for the improvement of maize resistance to the fungal pathogen Aspergillus flavus (A. flavus). In this study, 55 maize genes in plant–pathogen interaction
Felicia Parish +3 more
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Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite
Molecular Systems Biology, 2020 Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role.
Jessica M Bryant +8 more
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Sustainable deployment of QTLs conferring quantitative resistance to crops: first lessons from a stochastic model [PDF]
, 2014 Quantitative plant disease resistance is believed to be more durable than qualitative resistance, since it exerts less selective pressure on the pathogens.
Bourget, Romain +3 more
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Application of quantitative proteomics to discover biomarkers for tick resistance in cattle
Frontiers in Immunology, 2023 IntroductionBreeding for tick resistance is a sustainable alternative to control cattle ticks due to widespread resistance to acaricidal drugs and the lack of a protective vaccine.
Ali Raza +11 more
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Effects of the repeated distribution of sainfoin hay on the resistance and the resilience of goats naturally infected with gastrointestinal nematodes [PDF]
, 2005 Due to the high prevalence of anthelmintic resistance in goats, the need to explore novel approaches to control nematodes and to reduce the exclusive reliance on chemotherapy is strongly demanded in this host species.
F., De La Farge +4 more
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Host Cell Signalling and Leishmania Mechanisms of Evasion
Journal of Tropical Medicine, 2012 Leishmania parasites are able to secure their survival and propagation within their host by altering signalling pathways involved in the ability of macrophages to kill pathogens or to engage adaptive immune system.
Marina Tiemi Shio +7 more
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Evaluation of African-Bred Maize Germplasm Lines for Resistance to Aflatoxin Accumulation
Agronomy, 2016 Aflatoxins, produced by the fungus Aspergillus flavus, contaminate maize grain and threaten human food and feed safety. Plant resistance is considered the best strategy for reducing aflatoxin accumulation. Six maize germplasm lines, TZAR101–TZAR106, were
Robert L. Brown +4 more
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Host Resistance and Immune Aging [PDF]
Clinics in Geriatric Medicine, 2016 Human immune system aging results in impaired responses to pathogens or vaccines. In the innate immune system, which mediates the earliest pro-inflammatory responses to immunologic challenge, processes ranging from Toll-like Receptor function to Neutrophil Extracellular Trap formation are generally diminished in older adults.
Thilinie, Bandaranayake, Albert C, Shaw
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