Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process [PDF]
Pharmaceutics, 2018 Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing numerous types of drug delivery systems and dosage forms. It offers several advantages: no solvents are required, it is easy to scale up and employ on the industrial
Roberta Censi +3 more
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Material-Sparing Feasibility Screening for Hot Melt Extrusion [PDF]
PharmaceuticsHot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at ...
Amanda Pluntze +4 more
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Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion [PDF]
Pharmaceutics, 2023 Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients.
Judith Winck +2 more
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Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion [PDF]
Pharmaceutics, 2022 Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding.
Tobias Gottschalk +3 more
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Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate [PDF]
Pharmaceutics, 2022 The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME).
Lena Hoffmann +2 more
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Vertical Hot-Melt Extrusion: The Next Challenge in Innovation [PDF]
PharmaceuticsBackground/Objectives: Hot-melt extrusion (HME) has become a key technology in pharmaceutical formulation, particularly for enhancing the solubility of poorly soluble Active Pharmaceutical Ingredients (APIs).
Maël Gallas +3 more
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Hot-Melt Extrusion Enhances Antioxidant Effects of Mulberry on Probiotics and Pathogenic Microorganisms [PDF]
Antioxidants, 2022 Mulberry is a rich source of anthocyanins (ACNs) known to possess biological activities. However, these ACNs are unstable in high pH, heat, and aqueous environments with a low bioavailability.
Eun Ji Go +10 more
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Preparation of Solid Dispersion of Polygonum Cuspidatum Extract by Hot Melt Extrusion to Enhance Oral Bioavailability of Resveratrol [PDF]
Molecules, 2023 The aim of this study was to improve the solubility, bioavailability, and stability of resveratrol (RES-SD) Solid Dispersion in Polygonum cuspidatum extract (PCE) by hot melt extrusion (HME).
Wenling Fan +4 more
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Разработка и регистрация лекарственных средств, 2022 Introduction. The solubility of an active pharmaceutical ingredient plays a major role in drug absorption. Hot melt extrusion is a batch or continuous process that allows creating solid dispersion systems based on various carriers in order to increase ...
K. A. Gusev +7 more
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Recent development, challenges, and prospects of extrusion technology
Future Foods, 2021 There is a significant advancement in the modification of extruders for the commercial application in food processing sector, especially during the last three decades.
Krishna Prabha +6 more
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