Results 11 to 20 of about 30,308 (277)
Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
International Journal of Pharmaceutics: X, 2020 In product development, it is crucial to choose the appropriate drug manufacturing route accurately and timely and to ensure that the technique selected is suitable for achieving the desired product quality.
Josip Matić +6 more
doaj +3 more sources
Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion
International Journal of Pharmaceutics: X, 2021 Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality.
Josip Matić +5 more
doaj +3 more sources
Inline Determination of Residence Time Distribution in Hot-Melt-Extrusion [PDF]
Pharmaceutics, 2018 In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a ...
Jens Wesholowski +2 more
doaj +4 more sources
Factors That Influence Sustained Release from Hot-Melt Extrudates
Pharmaceutics, 2023 Hot-melt extrusion is a well-established tool in the pharmaceutical industry, mostly implemented to increase the solubility of poorly soluble drugs. A less frequent application of this technique is to obtain formulations with extended release. This study
Yaser Mansuroglu, Jennifer Dressman
doaj +1 more source
Hot Melt Extrusion Processing Parameters Optimization [PDF]
Processes, 2020 The aim of this study was to demonstrate the impact of processing parameters of the hot-melt extrusion (HME) on the pharmaceutical formulation properties. Carbamazepine (CBZ) was selected as a model water-insoluble drug. It was incorporated into Soluplus®, which was used as the polymeric carrier, to produce a solid dispersion model system.
Abdullah Alshetaili +3 more
openaire +1 more source
Journal of Materials Research and Technology, 2022 Grain refinement with a facile process without additional alloying is quite desired for strengthening the Al alloys. Using the melt spinning process, we obtained the ultra-fine grained foils of Al–Mg–Si–Cu alloy (AA6061), then the foils followed by hot ...
Shuoxun Jin +5 more
doaj +1 more source
A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation [PDF]
, 2020 Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants.
Clark, E. A. +10 more
core +2 more sources
Pharmaceutics, 2020 The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD ...
Sung-Min Choi +3 more
doaj +1 more source
Разработка и регистрация лекарственных средств, 2023 Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev +7 more
doaj +1 more source
Process monitoring and visualization solutions for hot-melt extrusion : a review [PDF]
, 2013 Objectives: Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations.
De Beer, Thomas +3 more
core +2 more sources