Influence of degassing on hot-melt extrusion process [PDF]
European Journal of Pharmaceutical Sciences, 2015 The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and
Saad M, Alshahrani +5 more
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Controlled release from zein matrices: Interplay of drug hydrophobicity and pH [PDF]
, 2015 Purpose: In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet the range of drugs for which zein has been studied remains small.
A Katchalsky +34 more
core +2 more sources
MICROSTRUCTURE AND THERMAL STABILITY OF Al-Fe-X ALLOYS
Acta Metallurgica Slovaca, 2018 In this work, Al-11Fe, Al-7Fe-4Ni and Al-7Fe-4Cr (in wt. %) alloys were prepared by combination of casting and hot extrusion. Microstructures of as-cast alloys were composed of aluminium matrix with large and coarse intermetallics such as Al13Fe4 ...
Andrea Školáková +5 more
doaj +1 more source
Novel Applications of Hot Melt Extrusion Technology
Journal of Drug Delivery and Therapeutics, 2023 Hot melt extrusion (HME) technology was introduced to pharmaceuticals in the 1970s for manufacturing and product development. Since then, there were several developments in HME technology to utilize it effectively for the manufacturing of pharmaceuticals.
Biplab Kumar Dey +4 more
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Extrusion - back to the future: using an established technique to reform automated chemical synthesis [PDF]
, 2016 YesHerein, the benefits which extrusion can provide for the automated continuous synthesis of organic compounds are highlighted. Extrusion is a well-established technique that has a vital role in the manufacturing processes of polymers, pharmaceuticals ...
Crawford, Deborah E.
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Applications of hot-melt extrusion for drug delivery [PDF]
Expert Opinion on Drug Delivery, 2008 In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously ...
Michael A, Repka +4 more
openaire +2 more sources
Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
Pharmaceutics, 2018 A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the ...
Esther S. Bochmann +2 more
doaj +1 more source
Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core [PDF]
, 2014 A
De Beer, Thomas +7 more
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The formation of a nanohybrid shish-kebab (NHSK) structure in melt-processed composites of poly (ethylene terephthalate) (PET) and multi-walled carbon nanotubes (MWCNTs) [PDF]
, 2017 The combination of synchrotron Small- and Wide-Angle X-ray scattering (SAXS/WAXS), and thermal analysis was used to follow the evolution of crystalline morphology and crystallization kinetics in a series of melt-processed composites of poly(ethylene ...
Bikondoa, Oier +7 more
core +2 more sources
Development and Validation of an In‐Line API Quantification Method Using AQbD Principles Based on UV‐Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Process [PDF]
, 2020 open access journalA key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls.
Almeida, Juan +5 more
core +2 more sources