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Application of HPMC HME polymer as hot melt extrusion carrier in carbamazepine solid dispersion
Drug Development and Industrial Pharmacy, 2020This work is to investigate the application characteristics of a new hot melt extrusion (HME) polymer (HME-grade hydroxypropyl methylcellulose, namely HPMC HME 15LV) in solid dispersion by HME.Carbamazepine (CBZ) was chosen as the model drug. And two types of solid dispersion system was prepared by HME, that is, single carrier system which was composed
Tianyuan Ci
exaly +3 more sources
International Journal of Pharmaceutics, 2023
Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commercial value.
Thiagarajan Madheswaran +2 more
exaly +3 more sources
Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commercial value.
Thiagarajan Madheswaran +2 more
exaly +3 more sources
A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation
Drug Development and Industrial Pharmacy, 2013 The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs is a major challenge in the development of such oral dosage forms. Taste assessment is an important quality-control parameter for evaluating taste-masked formulations of any new molecular entity. Hot-melt
Mohammed, Maniruzzaman +4 more
openaire +3 more sources
Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms [PDF]
, 2013 This research study explores the use of lipids in hot melt extrusion (HME) for the preparation of sustained release solid lipid matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium (Df-Na)/Compritol® 888 ATO (888 ATO) prepared using different ...
Vithani, Kapilkumar
core +8 more sources
Carbohydrate Polymers, 2014
HPMCAS is a widely used polymer in the pharmaceutical industry as an excipient. In this work, the physicochemical stability of HPMCAS was investigated for hot melt extrusion (HME) application. The reduction in zero rate viscosity (η0) of the polymer with the increase in temperature was determined using rheological evaluation prior to HME processing ...
Navnit Shāh, Harpreet Sandhu
exaly +3 more sources
HPMCAS is a widely used polymer in the pharmaceutical industry as an excipient. In this work, the physicochemical stability of HPMCAS was investigated for hot melt extrusion (HME) application. The reduction in zero rate viscosity (η0) of the polymer with the increase in temperature was determined using rheological evaluation prior to HME processing ...
Navnit Shāh, Harpreet Sandhu
exaly +3 more sources
Molecular Pharmaceutics, 2016
The production of amorphous solid dispersions via hot melt extrusion (HME) relies on elevated temperature and prolonged residence time, which can result in potential degradation and decomposition of thermally sensitive components. Herein, the rheological properties of a physical mixture of polymer and an active pharmaceutical ingredient (API) were ...
Yongchao Su +2 more
exaly +3 more sources
The production of amorphous solid dispersions via hot melt extrusion (HME) relies on elevated temperature and prolonged residence time, which can result in potential degradation and decomposition of thermally sensitive components. Herein, the rheological properties of a physical mixture of polymer and an active pharmaceutical ingredient (API) were ...
Yongchao Su +2 more
exaly +3 more sources
International Journal of Pharmaceutics, 2023
The objective of the current study is the formulation development and manufacturing of solid self-emulsifying drug delivery systems (HME S-SEDDS) via a single-step continuous hot-melt extrusion (HME) process. For this study, poorly soluble fenofibrate was selected as a model drug.
Dinesh Nyavanandi +2 more
exaly +3 more sources
The objective of the current study is the formulation development and manufacturing of solid self-emulsifying drug delivery systems (HME S-SEDDS) via a single-step continuous hot-melt extrusion (HME) process. For this study, poorly soluble fenofibrate was selected as a model drug.
Dinesh Nyavanandi +2 more
exaly +3 more sources
International Journal of Pharmaceutics
Hot melt extrusion (HME) processed Poly (lactic-co-glycolic acid) (PLGA) implant is one of the commercialized drug delivery products, which has solid, well-designed shape and rigid structures that afford efficient locoregional drug delivery on the spot of interest for months.
Thomas Durig, Fengyuan Yang
exaly +3 more sources
Hot melt extrusion (HME) processed Poly (lactic-co-glycolic acid) (PLGA) implant is one of the commercialized drug delivery products, which has solid, well-designed shape and rigid structures that afford efficient locoregional drug delivery on the spot of interest for months.
Thomas Durig, Fengyuan Yang
exaly +3 more sources
Hot-melt extrusion technique (HME) to develop intravitreal inserts
, 2015 This study aimed to develop an ophthalmic insert containing fluocinolone acetonide (FA), to apply in the posterior segment of the eye. The inserts were prepared by the hot-melt extrusion technique (HME) and contained 3% FA and different polymeric materials chosen according to their suitability for extrusion and their potential use in ophthalmic field ...
Monti, D +8 more
openaire +4 more sources
A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation
Drug Development and Industrial Pharmacy, 2014 The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs is a major challenge in the development of such oral dosage forms.
Martin Snowden +2 more
exaly +1 more source