Results 201 to 210 of about 174,417 (293)

Research progress on plant-derived bioactive compounds and late-life depression: from neuroprotective mechanisms to dietary patterns. [PDF]

Front Nutr
Gao Y, Shi YF, Hu JZ, Li ZK, Du XZ, Liu S.   +5 more
europepmc   +1 more source

Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non‐motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be ...
Bradley McDaniels, Gregory M. Pontone, Kuhan Pushparatnam, Indu Subramanian   +3 more
wiley   +1 more source

From the TPR pathway and the neuroimmune unit to the cutaneous HPA axis: a neuro-endo-immune cross-talk in rosacea. [PDF]

Front Med (Lausanne)
He Z, Feng YY, Ning T, Wu P, Yang C, Zhang Q.   +5 more
europepmc   +1 more source

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

A flexible repertoire of wound closure strategies precedes whole-body regeneration. [PDF]

Nat Commun
Kann AP, Srivastava M.
europepmc   +1 more source

The Mediating Role of Disengaged Coping in the Relationship Between Adverse Childhood Experiences and Substance Use Among Sexual Minority Adults

Research in Nursing &Health, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are strongly linked to negative long‐term health outcomes. Sexual minority (SM) individuals face disproportionate exposure to ACEs and their consequences compared to heterosexual peers. However, the mechanisms connecting ACEs to these outcomes remain poorly understood.
Marvin A. Schilt‐Solberg, Julie J. A. M. J. Kurzer   +1 more
wiley   +1 more source

Habitual physical activity and sarcopenia: a systematic review and meta-analysis of prospective cohort studies. [PDF]

J Glob Health
Dai D, Xie F, Cui J, Wang S, Cai J, Wang G, Yao F.   +6 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Neurobiological and Neuroimmune Mechanisms Linking Chronic Pain, Sleep Disturbances and Mental Health Disorders. [PDF]

Int J Mol Sci
Burnjakovic B, Moy H, Sic A, Knezevic NN.   +3 more
europepmc   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source