The HPA Axis as Target for Depression. [PDF]
Curr NeuropharmacolAbstract: Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence of 20% and, thus, is one of the most prevalent mental health disorders worldwide. Many studies with a large number of patients support the notion that abnormalities of the hypothalamus-pituitaryadrenal (HPA) axis are crucial for the development of ...
Menke A.
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Brain Sciences, 2021 The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic stress, which plays a key role in the pathophysiology of depression ...
Joanna Mikulska +3 more
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The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity. [PDF]
PLoS ONE, 2014 Hypothalamus-pituitary-adrenal (HPA) hyperactivity is observed in many patients suffering from depression and the mechanism underling the dysfunction of HPA axis is not well understood.
Li-Juan Zhu +11 more
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Bouncing back - trauma and the HPA-axis in healthy adults [PDF]
European Journal of Psychotraumatology, 2010 Dysregulation of the hypothalamic–pituitary–adrenal (HPA)-axis is thought to underlie stress-related psychiatric disorders such as posttraumatic stress disorder (PTSD). Some studies have reported HPA-axis dysregulation in trauma-exposed (TE)
Ellen Renée Klaassens
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Can variation in hypothalamic-pituitary-adrenal (HPA)-axis activity explain the relationship between depression and cognition in bipolar patients? [PDF]
PLoS ONE, 2012 Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is thought to be associated with more mood symptoms and worse cognitive functioning. This study examined whether variation in HPA axis activity underlies the association between mood symptoms
Marieke J van der Werf-Eldering +5 more
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The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk
Brain Sciences, 2020 Stress and Hypothalamic–Pituitary–Adrenal (HPA) axis dysregulation play a major role in various pathophysiological processes associated with both mood disorders and suicidal behavior.
Isabella Berardelli +5 more
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Chronic stress suppresses the expression of cutaneous hypothalamic-pituitary-adrenocortical axis elements and melanogenesis. [PDF]
PLoS ONE, 2014 Chronic stress can affect skin function, and some skin diseases might be triggered or aggravated by stress. Stress can activate the central hypothalamic-pituitary-adrenocortical (HPA) axis, which causes glucocorticoid levels to increase. The skin has HPA
Silin Pang +5 more
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Dream Recall/Affect and the Hypothalamic–Pituitary–Adrenal Axis
Clocks & Sleep, 2021 In this concise review, we present an overview of research on dream recall/affect and of the hypothalamic–pituitary–adrenal (HPA) axis, discussing caveats regarding the action of hormones of the HPA axis (mainly cortisol and its free form, cortisol ...
Athanasios Tselebis +2 more
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Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. [PDF]
PLoS ONE, 2017 Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood.
Osama A Abulseoud +6 more
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Marijuana Use and Hypothalamic-Pituitary-Adrenal Axis Functioning in Humans
Frontiers in Psychiatry, 2018 Preclinical studies suggest cannabinoids affect functioning of the hypothalamic-pituitary-adrenal (HPA) axis, but little is known about the effects of marijuana (MJ) use on HPA axis functioning in humans. Since previous work indicates substances of abuse
Anita Cservenka +2 more
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