Cancer Science, EarlyView.This study identifies downregulated autoantibodies in NSCLC and demonstrates their diagnostic and prognostic utility. Integrating proteome‐wide screening and large‐cohort validation, we highlight a novel biomarker class that enhances early detection and patient stratification.
Yihao Liang +7 more
wiley +1 more source
Long-Term Effects of Adverse Maternal Care on Hypothalamic-Pituitary-Adrenal (HPA) Axis Function of Juvenile and Adolescent Macaques. [PDF]
Biology (Basel)McCormack K +6 more
europepmc +1 more source
Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers
Cancer Science, EarlyView.Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu +5 more
wiley +1 more source
Risk as a First Derivative: Using Intensive Repeated Measures and Molecular Approaches to Studying Families [PDF]
, 2019 Robles, Theodore F
core
The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression
Clinical Endocrinology, EarlyView.ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, frequently accompanied by psychological comorbidities including depression. The aim of this narrative review is to summarise the latest research regarding potential contributors to and underpinning mechanisms of this relationship.
Asimina I. Karampela, Maralyn Druce
wiley +1 more source
Early prenatal but not postnatal glucocorticoid exposure is associated with enhanced HPA axis activity into adulthood in a wild primate. [PDF]
Proc Biol SciAnzà S +3 more
europepmc +1 more source
Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology
Clinical Endocrinology, EarlyView.ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth +7 more
wiley +1 more source
Caregivers' perspectives of support needs for adolescents with fetal alcohol spectrum disorder
Children &Society, EarlyView.Abstract Research focused on fetal alcohol spectrum disorder (FASD) is often deficit‐focused, limiting a holistic understanding of individuals' support needs. Families of adolescents with FASD also struggle to access appropriate services. Using semi‐structured interviews, the current study explored the perspectives of seven caregivers of adolescents ...
Kelly Skorka +4 more
wiley +1 more source
Association between maternal perceived stress during pregnancy and offspring DNA methylation changes in HPA axis genes at birth in the ECHO Consortium. [PDF]
Environ EpigenetJones K +14 more
europepmc +1 more source
The oral microbiome is associated with HPA axis response to a psychosocial stressor. [PDF]
Sci RepCharalambous EG +8 more
europepmc +1 more source