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Drugs and HPA axis

Pituitary, 2008
This paper outlines the interferences of the most widely used drugs with hypothalamo-pituitary-adrenal function and the related laboratory parameters, with the purpose of providing practical help to clinicians during testing for hypo- or hypercortisolemic states.
Alberto Giacinto, Ambrogio   +2 more
openaire   +3 more sources

The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders.

Current Opinion in Neurobiology, 2020
There is growing evidence for the involvement of the gut-microbiota in the regulation of emotions, behavior, and higher cognitive functions through the 'microbiome-gut-brain axis'. This relationship between the gut microbiota and the brain is pivotal for
Linoy Mia Frankiensztajn   +2 more
semanticscholar   +1 more source

Linking the hemodynamic consequences of adverse childhood experiences to an altered HPA axis and acute stress response.

Brain, behavior, and immunity, 2020
Adverse childhood experiences (ACEs), such as maltreatment and severe household dysfunction, represent a significant threat to public health as ACEs are associated with increased prevalence of several chronic diseases.
Kylie S. Dempster   +4 more
semanticscholar   +1 more source

HPA Axis‐Rhythms

Comprehensive Physiology, 2014
AbstractThe hypothalamic‐pituitary‐adrenal (HPA) axis regulates circulating levels of glucocorticoid hormones, and is the major neuroendocrine system in mammals that provides a rapid response and defense against stress. Under basal (i.e., unstressed) conditions, glucocorticoids are released with a pronounced circadian rhythm, characterized by peak ...
Francesca Spiga   +3 more
openaire   +1 more source

Fetal and Neonatal HPA Axis

Comprehensive Physiology, 2016
ABSTRACTStress is an integral part of life. Activation of the hypothalamus‐pituitary‐adrenal (HPA) axis in the adult can be viewed as mostly adaptive to restore homeostasis in the short term. When stress occurs during development, and specifically during periods of vulnerability in maturing systems, it can significantly reprogram function, leading to ...
Charles E, Wood   +1 more
openaire   +2 more sources

Sex Differences in the HPA Axis

Comprehensive Physiology, 2014
AbstractThe hypothalamic‐pituitary‐adrenal (HPA) axis is a major component of the systems that respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly controlled regulation of HPA responses is critical for maintaining mental and physical health, as hyper‐ and hypo‐activity have been linked to disease states.
Nirupa, Goel   +4 more
openaire   +2 more sources

Neglect, HPA axis reactivity, and development

International Journal of Developmental Neuroscience, 2019
Neglect is a common and frequently chronic form of child maltreatment that can compromise child development and increase the risk of physical and psychological problems. In this review, we discuss one of the potential ways neglect becomes biologically embedded by shaping the development of a key stress responsive system: namely, the hypothalamic ...
Emily B, Reilly, Megan R, Gunnar
openaire   +2 more sources

HPA Axis Interactions with Behavioral Systems

Comprehensive Physiology, 2016
ABSTRACTPerhaps the most salient behaviors that individuals engage in involve the avoidance of aversive experiences and the pursuit of pleasurable experiences. Engagement in these behaviors is regulated to a significant extent by an individual's hormonal milieu.
Amy E B, Packard   +2 more
openaire   +2 more sources

Pathophysiological implications of neuroinflammation mediated HPA axis dysregulation in the prognosis of cancer and depression.

Molecular and Cellular Endocrinology, 2020
Cancer patients are more likely to develop depressive symptoms and show a poor prognosis compared to the normal healthy individuals. Cancer occurrence and the anticancer treatments result in the pro-inflammatory cytokines-mediated inflammation, which ...
Mir Hilal Ahmad   +3 more
semanticscholar   +1 more source

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