Results 81 to 90 of about 66,213 (258)

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Sleep, Neuroendocrine Disorders, And the Bidirectional Relationship between the Hypothalamic-Pituitary-Adrenal Axis: A Mini-Review

Journal of Applied Sciences and Environmental Management
This review explores the intricate and bidirectional relationships between the hypothalamic-pituitary-adrenal (HPA) axis, sleep architecture and regulation, and the manifestation of various neuroendocrine disorders. The HPA axis, a critical component of
O. A. Udi
doaj   +4 more sources

Sex differences in the murine HPA axis after acute and repeated restraint stress

Stress
Chronic stress and stress-related mental illnesses such as major depressive disorder (MDD) constitute some of the leading causes of disability worldwide with a higher prevalence in women compared to men.
Isabella Flor Nalepa, Vibeke Nielsen, Tanja Esther Wolf, Chadi Touma, Morten Grupe, Ayodeji A. Asuni, Cecilia Ratner   +6 more
doaj   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Impact of Childhood Family Conflict on Adolescents' Startle Reactivity to Threat: The Moderating Role of Sensory Processing Sensitivity

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Chronic familial conflict is known to hinder the development of adaptive stress responding in adolescents. However, there are differences in how individuals respond to familial conflict, which may be explained by the temperament trait of Sensory Processing Sensitivity (SPS).
Sophia A. Bibb, Kathryn C. Jenkins, Alexa House, Kayla A. Kreutzer, K. Luan Phan, Stephanie M. Gorka   +5 more
wiley   +1 more source

Exploring the Role of Dysregulated Arousal in the Relationship Between Trauma and Addictive Behaviors Among College Students

Journal of Counseling &Development, EarlyView.
ABSTRACT The relationship between trauma and addictive behaviors is well‐established, yet factors mediating this relationship remain understudied. Given the prevalence of addictive behaviors among collegiate populations, we used path analysis to explore the mediating role of arousal dysregulation in the relationship between childhood trauma and a ...
Amanda L. Giordano, Kate M. Dorrough, Deborah L. Smith, Peitao Zhu   +3 more
wiley   +1 more source

Interventions for pre‐school children in foster care: A systematic review of the foster carer and system level outcomes from randomised controlled trials

JCPP Advances, EarlyView.
Abstract Background Children in foster care are at increased risk of experiencing cognitive, emotional and behavioural difficulties. There is a window of opportunity for early intervention associated with developmental sensitivity in the early years. Foster carers and the systems supporting them play a central role in intervention and support for the ...
Camilla Biggs, Natalie Kirby, Megan Garside, Gloria Cheung, Fiona Turner, Nishant Jaiswal, Helen Minnis   +6 more
wiley   +1 more source

Steroidopathies and hormonal imbalance in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a multifactorial etiology, many aspects of which remain unclear. Emerging evidence suggests a potential association between ASD and clinical manifestations resulting from hormonal imbalances, henceforth named “steroidopathies.” The present study aims to ...
Concetta de Giambattista, Patrizia Ventura, Samuele Cortese, Paolo Trerotoli, Alessandra Di Gioia, Lucia Margari   +5 more
wiley   +1 more source

Food Insecurity was Associated With Poorer Sleep Quality and Increased Stress Among Dental Students at a HBCU and a Predominantly White School

Journal of Dental Education, EarlyView.
ABSTRACT Purpose The prevalence of food insecurity (FI) and its associated outcomes among undergraduate students have been widely researched, however studies focusing on FI among professional students are limited. This study investigated the associations between FI, sleep‐related variables, and stress among dental students from predominantly Black and ...
Brian Laurence, Teresa A. Marshall, Fang Qian, Gillian Robinson‐Warner, Archana Kumar, Nidhi Handoo, Cari Anderson   +6 more
wiley   +1 more source