Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients [PDF]
Diagnostic Pathology, 2018 Background Heat shock factor 1 (HSF1) was initially identified as a transcription factor encoding heat shock proteins, which assist in refolding or degrading damaged proteins.
Weigang Dai +10 more
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HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program [PDF]
Experimental and Molecular MedicineHeat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis.
Sue Jin Moon +6 more
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HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model [PDF]
Mediators of Inflammation, 2023 Background. Sepsis, which could cause a systemic inflammatory response, is a life-threatening disease with a high morbidity and mortality rate. There is evidence that brain injury may be related to severe systemic infection induced by sepsis.
Yi-fu He +8 more
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New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases. [PDF]
Cell Biochem FunctABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Kumar PS +5 more
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Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response
eLife, 2018 Models for regulation of the eukaryotic heat shock response typically invoke a negative feedback loop consisting of the transcriptional activator Hsf1 and a molecular chaperone.
Joanna Krakowiak +8 more
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Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair [PDF]
Cell Death and DiseaseDiffuse large B-cell lymphoma (DLBCL) is commonly treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), but up to 40% of patients have refractory or relapsing disease and show unsatisfactory responses to salvage ...
Yu Fang +10 more
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Role of HSF1 in cell division, tumorigenesis and therapy: a literature review [PDF]
Cell DivisionHeat shock factor 1 (HSF1) is the master orchestrator of the heat shock response (HSR), a critical process for maintaining cellular health and protein homeostasis.
Otakar Fiser, Petr Muller
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HSF1 Activation Mechanisms, Disease Roles, and Small Molecule Therapeutics. [PDF]
Int J Biol SciZhang B, Fan Y, Tan K.
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Microbiology Spectrum, 2023 Autophagy plays an important role in endotoxemic mice, and heat shock factor 1 (HSF1) plays a crucial protective role in endotoxemic mice. However, the protective mechanisms of HSF1 are poorly understood.
Hong Tan +4 more
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HSF1 protects cells from cadmium toxicity by governing proteome integrity
Ecotoxicology and Environmental Safety, 2023 Background: Cadmium toxicity has been associated with disruption of protein homeostasis by interfering with protein folding processes. Heat shock factor 1 (HSF1) coordinates the rapid and extensive cellular response to maintain proteomic balance facing ...
Yuchun Zhang +8 more
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