Results 91 to 100 of about 12,403 (212)

MicroRNA‑615‑5p regulates the proliferation and apoptosis of breast cancer cells by targeting HSF1

, 2021
Kaisheng Liu, Rong Ma
openalex   +2 more sources

Functional Difference of MYC and MYCN in Combined Hepatocellular–Cholangiocarcinoma: Regulation of Differentiation by HNF1B

Cancer Science, Volume 117, Issue 2, Page 536-547, February 2026.
Combined hepatocellular–cholangiocarcinoma (cHCC‐CCA) is a tumor consisting of a mixture of hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CCA) components, but the mechanisms of development are poorly understood. The activation of Myc may be implicated in the formation of cHCC‐CCA and this work demonstrates for the first time that Myc ...
Masanori Goto, Masahiro Yamamoto, Hiroki Tanaka, Yumiko Fujii, Kumi Takasawa, Yuki Kamikokura, Masayo Kamikokura, Nobuyuki Kobayashi, Taro Murakami, Yuji Nishikawa, Akira Takasawa   +10 more
wiley   +1 more source

Gpx4 Deletion‐Mediated Macrophage Ferroptosis Alleviates Obesity‐Associated Insulin Resistance

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Macrophage‐specific loss of Gpx4 induces ferroptosis, thereby alleviating high‐fat diet (HFD)‐induced obesity, insulin resistance, and metabolic dysfunction, and conferring systemic metabolic protection in type 2 diabetes (T2D). ABSTRACT Obesity has become a global epidemic and a major contributor to the development of Type 2 diabetes (T2D) through the
Suhua Wu, Juan Peng, Xiaodong Wang, Hong Gao, Huangrui Fang, Shiyi Hu, Qiufen Wei, Yuanye Dang, Haixia Tu, Mingyan Zhu, Jianye Peng, Yumiao Liu, Gaofeng Zeng, Xiaoyan Dai   +13 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

HSF1 is required for cellular adaptation to daily temperature fluctuations

Scientific Reports
The heat shock response (HSR) is a universal mechanism of cellular adaptation to elevated temperatures and is regulated by heat shock transcription factor 1 (HSF1) or HSF3 in vertebrate endotherms, such as humans, mice, and chickens.
Ryosuke Takii, Mitsuaki Fujimoto, Akanksha Pandey, Kritika Jaiswal, Linda Shearwin-Whyatt, Frank Grutzner, Akira Nakai   +6 more
doaj   +1 more source

Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2020
Miaomiao Li,1,* Juntao Hu,2,* Riming Jin,3,* Hongxia Cheng,1 Huaping Chen,4 Limin Li,4 Kun Guo1 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People ...
Li M, Hu J, Jin R, Cheng H, Chen H, Li L, Guo K   +6 more
doaj  

RNAi based transcriptome suggests genes potentially regulated by HSF1 in the Pacific oyster Crassostrea gigas under thermal stress

BMC Genomics, 2019
Background The Pacific oyster Crassostrea gigas is an important fishery resource that is sensitive to temperature fluctuations. Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock
Youli Liu, Li Li, Baoyu Huang, Wei Wang, Guofan Zhang   +4 more
doaj   +1 more source

Hyperthermia increases HSP production in human PDMCs by stimulating ROS formation, p38 MAPK and Akt signaling, and increasing HSF1 activity [PDF]

, 2022
Ju‐Fang Liu, Po‐Chun Chen, Thai‐Yen Ling, Chun‐Han Hou   +3 more
openalex   +1 more source

Hyperthermia increases HSP production in human PDMCs by stimulating ROS formation, p38 MAPK and Akt signaling, and increasing HSF1 activity [PDF]

, 2021
Ju‐Fang Liu, PoChun Chen, Thai‐Yen Ling, Chun‐Han Hou   +3 more
openalex   +1 more source

Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN

Cancer Medicine
Background Heat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.Aims:To explore the involvement of the HSF ...
Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He   +4 more
doaj   +1 more source