Results 101 to 110 of about 12,403 (212)

Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter [PDF]

, 2022
Hongyang Shu, Yizhong Peng, Weijian Hang, Min Zhang, Lan Shen, Dao Wen Wang, Ning Zhou   +6 more
openalex   +1 more source

A Novel HSF1-mediated Death Pathway

Yamaguchi Medical Journal, 2007
熱ショック転写因子 (heat shock transcription factor, HSF) は，一群の熱ショック蛋白質 (heat shock protein, Hsp) の発現制御に関わる転写因子群として知られ，哺乳動物細胞では３種類のHSF (HSF1, HSF2, HSF4) が明らかにされている．このうち，HSF1は蛋白質の変性を感知し，Hspの発現制御において中心的な役割を担い，温熱ストレスをはじめとする様々なストレスに対する耐性の獲得を通して細胞生存に働いている．一方，我々は活性型HSF1トランスジェニックマウス，ならびに HSF1欠損マウスの解析から，HSF1が細胞死を導く働きがあることを示唆する結果を得ていた．本稿では ...
openaire   +2 more sources

Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective [PDF]

, 2020
Paul Workman
openalex   +1 more source

Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

Scientific Reports
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted therapy.
Pedro H. L. Viana, Csaba A. Schvarcz, Lea O. Danics, Balázs Besztercei, Kenan Aloss, Syeda M. Z. Bokhari, Nino Giunashvili, Dániel Bócsi, Zoltán Koós, Zoltán Benyó, Péter Hamar   +10 more
doaj   +1 more source

HSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis

Frontiers in Bioscience-Scholar
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in ...
Ksenia Kobzeva, Maxim Ivenkov, Rostislav Gromov, Olga Bushueva   +3 more
doaj   +1 more source

Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21^Cip1/WAF1pathways [PDF]

, 2013
Maria A. Zamkova, Н. В. Хромова, Kopnin Bp, Pavel Kopnin   +3 more
openalex   +1 more source

Suppression of HSF1 activity by wildtype p53 creates the driving force for p53 loss-of-heterozygosity, enabling mutant p53 stabilization and invasion [PDF]

, 2020
Özge Çiçek Şener, Adrian Stender, Luisa Klemke, Nadine Stark, Tamara Isermann, Jinyu Li, Ute M. Moll, Ramona Schulz‐Heddergott   +7 more
openalex   +1 more source

Widening HSF1 horizon: the microRNA connection

RNA & DISEASE, 2015
Heat shock factor 1 (HSF1) is an evolutionary conserved transcription factor, which acts as protector of cellular proteome against adverse environmental conditions including increased temperature in eukaryotes. HSF1 positively regulates expression of a set of cytoprotective proteins popularly called as heat shock proteins (HSPs) as part of an adaptive ...
openaire   +1 more source

Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

Communications Biology
There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target.
J. Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang   +12 more
doaj   +1 more source

TG02 inhibits proteasome inhibitor–induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma [PDF]

, 2017
Shardule P. Shah, Ajay K. Nooka, Sagar Lonial, Lawrence Boise   +3 more
openalex   +1 more source