Results 11 to 20 of about 12,403 (212)
HSF1 Activation Can Restrict HIV Replication
ACS Infectious Diseases, 2020 Host protein folding stress responses can play important roles in RNA virus replication and evolution. Prior work suggested a complicated interplay between the cytosolic proteostasis stress response, controlled by the transcriptional master regulator heat shock factor 1 (HSF1), and human immunodeficiency virus-1 (HIV-1).
Emmanuel E. Nekongo +5 more
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Molecularchaperones as HSF1-specific transcriptional repressors [PDF]
Genes & Development, 1998 The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an inert negatively regulated monomer to a transcriptionally active DNA-binding trimer. During attenuation of the heat shock response, transcription of heat shock genes returns to basal levels and HSF1 reverts to an inert monomer.
Yanhong Shi +2 more
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Quantitative Comparison of HSF1 Activators [PDF]
Molecular Biotechnology, 2022 AbstractThe heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones. Furthermore, it was demonstrated to play crucial roles in various diseases like neurodegeneration and cancer.
Christoph Steurer +7 more
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Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis
Hepatology Communications, 2022 Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs).
Asmita Choudhury +10 more
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Cancer Cell, 2013 The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood. A recent study connects increased protein translation to activation of HSF1 in malignant cells and demonstrates the therapeutic benefit of targeting this ...
de Billy, Emmanuel +2 more
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Journal of Cell Science, 2014 ABSTRACTHeat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes. The central position of HSF1 in cellular homeostasis has been well demonstrated, mainly through its strong effect in transactivating genes that encode ...
Vihervaara A, Sistonen L
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MethodsX, 2021 Heat shock factor 1, HSF1, is one of several family members that recognize repeated nGAAn sequences associated with the heat shock element of heat shock and other genes.
Rachana Trivedi +4 more
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Heat Shock Proteins and HSF1 in Cancer [PDF]
Frontiers in Oncology, 2022 Fitness of cells is dependent on protein homeostasis which is maintained by cooperative activities of protein chaperones and proteolytic machinery. Upon encountering protein-damaging conditions, cells activate the heat-shock response (HSR) which involves HSF1-mediated transcriptional upregulation of a group of chaperones – the heat shock proteins (HSPs)
Anna M. Cyran, Anatoly Zhitkovich
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Cells, 2022 Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response.
Patryk Janus +8 more
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Molecular Cancer, 2020 Background Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1.
Ping Song +11 more
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