Results 191 to 200 of about 12,403 (212)

HSF1, Aging, and Neurodegeneration

2022
Heat shock factor 1 (HSF1) is a master transcription regulator that mediates the induction of heat shock protein chaperones for quality control (QC) of the proteome and maintenance of proteostasis as a protective mechanism in response to stress.
Alice Y, Liu, Conceição A, Minetti, David P, Remeta, Kenneth J, Breslauer, Kuang Yu, Chen   +4 more
openaire   +2 more sources

Trans-HSF1 Express

Science, 2013
Ribosome activity is linked to the activity of a transcription factor in cancer cells. [Also see Research Article by Santagata et al. ]
Valentina Gandin, Ivan Topisirovic
openaire   +1 more source

HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression

Cancer Research, 2008
Abstract Previously, heat shock factor 1 (HSF1) had been reported to induce genomic instability and aneuploidy by interaction with Cdc20. Here, we have further examined the functions of HSF1 in the regulation of mitosis. A null mutant or knockdown of HSF1 caused defective mitotic progression. By monitoring chromosomes in living cells,
Yoon-Jin, Lee, Eun-Ho, Kim, Jae Seon, Lee, Dooil, Jeoung, Sangwoo, Bae, Seung Hae, Kwon, Yun-Sil, Lee   +6 more
openaire   +2 more sources

Maternal effect of Hsf1 on reproductive success

Nature, 2000
A protein known as heat-shock factor-1 (HSF1) is a major transactivator of stress-inducible genes in response to environmental changes, but it is also implicated in extra-embryonic development and female fertility in mice1,2. Here we show that mouse embryos whose mothers lack this protein are unable to develop properly beyond the zygotic stage ...
E, Christians, A A, Davis, S D, Thomas, I J, Benjamin   +3 more
openaire   +2 more sources

HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function)

Atherosclerosis, 2007
We have been examining the role of heat shock factor 1 (HSF1) in the pleiotropic effects of statins. In parallel studies, we found that statin induces the nuclear translocation of HSF1 and that a decoy oligonucleotide encoding the heat shock element inhibits the statin-induced expression of heat shock protein 70, endothelial nitric oxide synthase (eNOS)
Tsuyoshi, Uchiyama, Hiroyuki, Atsuta, Toshihiro, Utsugi, Masato, Oguri, Akira, Hasegawa, Tetsuya, Nakamura, Akira, Nakai, Masanori, Nakata, Ikuro, Maruyama, Hideaki, Tomura, Fumikazu, Okajima, Shoichi, Tomono, Shoji, Kawazu, Ryozo, Nagai, Masahiko, Kurabayashi   +14 more
openaire   +2 more sources

HSF1 Relieves Amyloid-β-Induced Cardiomyocytes Apoptosis

Cell Biochemistry and Biophysics, 2015
Accumulation of amyloid-β in organs results in a series of diseases. Heat shock transcription factor 1 (HSF1) is the master regulator of genes encoding molecular chaperones and attenuates apoptosis induced by multiple factors. However, the role of HSF1 on amyloid-β-induced apoptosis is still unknown.
Beiru, Zhang, Ping, He, Yonghao, Lu, Xiaohui, Bian, Xu, Yang, Xiaoying, Fu, Yan, Wu, Detian, Li   +7 more
openaire   +2 more sources

HSF1 Signaling Inhibits Apoptosis in Hepatoblastoma

The FASEB Journal, 2022
Introduction Hepatoblastoma (HB) is the most common pediatric liver malignancy. While relatively rare, its incidence is increasing. Currently surgical resection with or without chemotherapy is the main treatment for the tumor though in severe cases children require liver transplantation. Development of precision
Edward Hurley, Junyan Tao, Silvia S. Liu, Yekaterina Krutsenko, Satdarshan P. Monga   +4 more
openaire   +1 more source

HSF1 and Its Role in Huntington’s Disease Pathology

2022
Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR) in mammalian cells and is a critical element in maintaining protein homeostasis. HSF1 functions at the center of many physiological processes like embryogenesis, metabolism, immune response, aging, cancer, and neurodegeneration.
Hyuck, Kim, Rocio, Gomez-Pastor
openaire   +2 more sources

Redox signaling of cardiac HSF1 DNA binding

American Journal of Physiology-Cell Physiology, 2002
Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein ( hsp) genes are the result of oxidation and/or depletion of ...
Zain, Paroo, Michael J, Meredith, Marius, Locke, James V, Haist, Morris, Karmazyn, Earl G, Noble   +5 more
openaire   +2 more sources