Results 211 to 220 of about 20,857 (230)

Methylene blue increases the amount of HSF1 through promotion of PKA-mediated increase in HSF1-p300 interaction

The International Journal of Biochemistry & Cell Biology, 2017
Heat shock factor 1 (HSF1) critically contributes to the host defense, and its amount determines the mobilization efficiency of HSF1 under stress conditions. To date, how HSF1 amount is regulated remains largely unknown. We found that methylene blue (MB), an anti-oxidative and anti-inflammatory agent, increased the amount of HSF1 in BV-2 microglia ...
Chao, Huang, Wenfeng, Hu, Jili, Wang, Lijuan, Tong, Xu, Lu, Feng, Wu, Yong, Ling, Bo, Jiang, Wei, Zhang, Zhuo, Chen, Qiuju, Xiong, Yibin, Qin, Rongrong, Yang   +12 more
openaire   +2 more sources

Regulation of HSF1 protein stabilization: An updated review

European Journal of Pharmacology, 2018
Heat shock factor 1 (HSF1) is a transcriptional factor that determines the efficiency of heat shock responses (HSRs) in the cell. Given its function has been extensively studied in recent years, HSF1 is considered a potential target for the treatment of disorders associated with protein aggregation.
Chao, Huang, Jingjing, Wu, Li, Xu, Jili, Wang, Zhuo, Chen, Rongrong, Yang   +5 more
openaire   +2 more sources

HSF1 and HSP Gene Regulation

2007
Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
openaire   +1 more source

Regulation of Hsf1 and the Heat Shock Response

2020
The heat shock response (HSR) is characterized by the induction of molecular chaperones following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of genes controlled by the transcription factor Hsf1. The HSR is induced by defects in co-translational protein folding, ribosome biogenesis, organellar targeting of nascent ...
openaire   +2 more sources

HSF1 GENE SILENCING

Pancreas, 2008
V Dudeja, S Skube, R Chugh, Y Yokoyama, R Talukdar, N Majumdar, D. Borja-Cacho, M. B. Antonoff, R. Dawra, S. Vickers, A. Saluja   +10 more
openaire   +1 more source

HSF1: An Emerging Factor In Cancer

2007
Heat shock factor1, the transcriptional activator of the heat shock protein (hsp) genes is expressed to high level in a number of types of malignancy. HSF1 elevation is coupled to the activation of the c-erb-B2 pathway, a common change associated with breast cancer.
Stuart K. Calderwood, Md Abdul Khaleque, Ajit Bharti, Daniel R. Ciocca   +3 more
openaire   +1 more source

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program

Cancer Communications, 2022
Ming Huang, Wuguo Li, Kai Yao
exaly  

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

Cell Stem Cell, 2021
Kristopher A Sarosiek, Christopher Dillingham, Bijou   +2 more
exaly  

Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock

Nature Cell Biology, 2022
Hongchen Zhang, Shipeng Shao, Yong Zeng
exaly  

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

Cell, 1998
Richard Voellmy
exaly