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HSF1: An Emerging Factor In Cancer
2007Heat shock factor1, the transcriptional activator of the heat shock protein (hsp) genes is expressed to high level in a number of types of malignancy. HSF1 elevation is coupled to the activation of the c-erb-B2 pathway, a common change associated with breast cancer.
Stuart K. Calderwood +3 more
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The International Journal of Biochemistry & Cell Biology, 2017
Heat shock factor 1 (HSF1) critically contributes to the host defense, and its amount determines the mobilization efficiency of HSF1 under stress conditions. To date, how HSF1 amount is regulated remains largely unknown. We found that methylene blue (MB), an anti-oxidative and anti-inflammatory agent, increased the amount of HSF1 in BV-2 microglia ...
Chao, Huang +12 more
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Heat shock factor 1 (HSF1) critically contributes to the host defense, and its amount determines the mobilization efficiency of HSF1 under stress conditions. To date, how HSF1 amount is regulated remains largely unknown. We found that methylene blue (MB), an anti-oxidative and anti-inflammatory agent, increased the amount of HSF1 in BV-2 microglia ...
Chao, Huang +12 more
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Linking HSF1 Activation to Translation
Science's STKE, 2006Cells can survive heat stress by increasing the abundance of heat shock proteins (HSPs) and other cytoprotective proteins to prevent toxicity from excess improperly folded proteins. In addition, heat shock inhibits translation and disrupts the cytoskeleton.
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Role of HSF1 in Infectious Disease
2009The single heat shock transcription factor (HSF) in lower Metazoans and the heat-activated HSF family member in higher vertebrates, HSF1, not only play a central role in regulating the expression of heat shock protein (HSP) genes in response to stress, but may also play an important role in regulating the host immune response to infection.
Ishwar S. Singh +3 more
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Hsf1 in Her2-positive Breast Cancer
2011Abstract : This study demonstrates that Hsf1 controls development of Her2-positive cancer both at the stage of initiation, via control of the oncogene-induced senescence, and progression, via regulation of tumor angiogenesis. It also dissects the mechanism of effects of Hsf1 on tumor angiogenesis, and demonstrates that Hsf1 regulates expression of the ...
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Redox signaling of cardiac HSF1 DNA binding
American Journal of Physiology-Cell Physiology, 2002Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein ( hsp) genes are the result of oxidation and/or depletion of ...
Zain, Paroo +5 more
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2007
Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
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Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
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[Human HSF1 mutants and their applications].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2009Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional
Yun-Hong, Huang +2 more
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Emerging roles of HSF1 in cancer: Cellular and molecular episodes
Biochimica Et Biophysica Acta: Reviews on Cancer, 2020Yumei Fan, Ke Tan, Pengxiu Cao
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