Results 191 to 200 of about 13,678 (223)

Regulation of HSF1 protein stabilization: An updated review

European Journal of Pharmacology, 2018
Heat shock factor 1 (HSF1) is a transcriptional factor that determines the efficiency of heat shock responses (HSRs) in the cell. Given its function has been extensively studied in recent years, HSF1 is considered a potential target for the treatment of disorders associated with protein aggregation.
Chao Huang, Jili Wang, Rongrong Yang
exaly   +3 more sources

Modulation of Hsf1 activity by novobiocin and geldanamycin

Biochemistry and Cell Biology, 2009
Since Hsp90 is a known modulator of HSF1 activity, we examined the effects of two pharmacological inhibitors of Hsp90, novobiocin and geldanamycin, on HSF1 DNA-binding activity in the Xenopus oocyte model system. Novobiocin exhibits antiproliferative activity in culture cells and interacts with a C-terminal ATP-binding pocket on Hsp90, inhibiting ...
Renaud, Conde, Zachery R, Belak, Manoj, Nair, Ruth F, O'Carroll, Nick, Ovsenek   +4 more
openaire   +2 more sources

HSF1 and Its Role in Huntington’s Disease Pathology

2022
Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR) in mammalian cells and is a critical element in maintaining protein homeostasis. HSF1 functions at the center of many physiological processes like embryogenesis, metabolism, immune response, aging, cancer, and neurodegeneration.
Hyuck, Kim, Rocio, Gomez-Pastor
openaire   +2 more sources

Regulation of Hsf1 and the Heat Shock Response

2020
The heat shock response (HSR) is characterized by the induction of molecular chaperones following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of genes controlled by the transcription factor Hsf1. The HSR is induced by defects in co-translational protein folding, ribosome biogenesis, organellar targeting of nascent ...
openaire   +2 more sources

Use of Hsf1−/− mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury

Toxicology and Applied Pharmacology, 2003
Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological ...
Wirth, D., Christians, E., Li, Xiang, Benjamin, I. J., Gustin, Pascal   +4 more
openaire   +2 more sources

Methylene blue increases the amount of HSF1 through promotion of PKA-mediated increase in HSF1-p300 interaction

The International Journal of Biochemistry & Cell Biology, 2017
Heat shock factor 1 (HSF1) critically contributes to the host defense, and its amount determines the mobilization efficiency of HSF1 under stress conditions. To date, how HSF1 amount is regulated remains largely unknown. We found that methylene blue (MB), an anti-oxidative and anti-inflammatory agent, increased the amount of HSF1 in BV-2 microglia ...
Chao, Huang, Wenfeng, Hu, Jili, Wang, Lijuan, Tong, Xu, Lu, Feng, Wu, Yong, Ling, Bo, Jiang, Wei, Zhang, Zhuo, Chen, Qiuju, Xiong, Yibin, Qin, Rongrong, Yang   +12 more
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HSF1: An Emerging Factor In Cancer

2007
Heat shock factor1, the transcriptional activator of the heat shock protein (hsp) genes is expressed to high level in a number of types of malignancy. HSF1 elevation is coupled to the activation of the c-erb-B2 pathway, a common change associated with breast cancer.
Stuart K. Calderwood, Md Abdul Khaleque, Ajit Bharti, Daniel R. Ciocca   +3 more
openaire   +1 more source

Hsf1 in Her2-positive Breast Cancer

2011
Abstract : This study demonstrates that Hsf1 controls development of Her2-positive cancer both at the stage of initiation, via control of the oncogene-induced senescence, and progression, via regulation of tumor angiogenesis. It also dissects the mechanism of effects of Hsf1 on tumor angiogenesis, and demonstrates that Hsf1 regulates expression of the ...
openaire   +1 more source

Redox signaling of cardiac HSF1 DNA binding

American Journal of Physiology-Cell Physiology, 2002
Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein ( hsp) genes are the result of oxidation and/or depletion of ...
Zain, Paroo, Michael J, Meredith, Marius, Locke, James V, Haist, Morris, Karmazyn, Earl G, Noble   +5 more
openaire   +2 more sources

Linking HSF1 Activation to Translation

Science's STKE, 2006
Cells can survive heat stress by increasing the abundance of heat shock proteins (HSPs) and other cytoprotective proteins to prevent toxicity from excess improperly folded proteins. In addition, heat shock inhibits translation and disrupts the cytoskeleton.
openaire   +1 more source