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HSF1 as a Cancer Biomarker and Therapeutic Target [PDF]

Current Cancer Drug Targets, 2019
Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat shock response. In this classical role, HSF1 is activated following cellular stresses such as heat shock that ultimately lead to HSF1-mediated expression of heat shock proteins to protect the proteome and survive these acute stresses. However, it is now becoming clear
Richard L Carpenter, Yesim Gokmen-Polar
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HSF1, the troublemaker next door

Nature Reviews Cancer, 2014
exaly   +2 more sources

HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function)

Atherosclerosis, 2007
We have been examining the role of heat shock factor 1 (HSF1) in the pleiotropic effects of statins. In parallel studies, we found that statin induces the nuclear translocation of HSF1 and that a decoy oligonucleotide encoding the heat shock element inhibits the statin-induced expression of heat shock protein 70, endothelial nitric oxide synthase (eNOS)
Tsuyoshi, Uchiyama, Hiroyuki, Atsuta, Toshihiro, Utsugi, Masato, Oguri, Akira, Hasegawa, Tetsuya, Nakamura, Akira, Nakai, Masanori, Nakata, Ikuro, Maruyama, Hideaki, Tomura, Fumikazu, Okajima, Shoichi, Tomono, Shoji, Kawazu, Ryozo, Nagai, Masahiko, Kurabayashi   +14 more
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HSF1 Relieves Amyloid-β-Induced Cardiomyocytes Apoptosis

Cell Biochemistry and Biophysics, 2015
Accumulation of amyloid-β in organs results in a series of diseases. Heat shock transcription factor 1 (HSF1) is the master regulator of genes encoding molecular chaperones and attenuates apoptosis induced by multiple factors. However, the role of HSF1 on amyloid-β-induced apoptosis is still unknown.
Beiru, Zhang, Ping, He, Yonghao, Lu, Xiaohui, Bian, Xu, Yang, Xiaoying, Fu, Yan, Wu, Detian, Li   +7 more
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HSF1 Signaling Inhibits Apoptosis in Hepatoblastoma

The FASEB Journal, 2022
Introduction Hepatoblastoma (HB) is the most common pediatric liver malignancy. While relatively rare, its incidence is increasing. Currently surgical resection with or without chemotherapy is the main treatment for the tumor though in severe cases children require liver transplantation. Development of precision
Edward Hurley, Junyan Tao, Silvia S. Liu, Yekaterina Krutsenko, Satdarshan P. Monga   +4 more
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HSF1 and Its Role in Huntington’s Disease Pathology

2022
Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR) in mammalian cells and is a critical element in maintaining protein homeostasis. HSF1 functions at the center of many physiological processes like embryogenesis, metabolism, immune response, aging, cancer, and neurodegeneration.
Hyuck, Kim, Rocio, Gomez-Pastor
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Redox signaling of cardiac HSF1 DNA binding

American Journal of Physiology-Cell Physiology, 2002
Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein ( hsp) genes are the result of oxidation and/or depletion of ...
Zain, Paroo, Michael J, Meredith, Marius, Locke, James V, Haist, Morris, Karmazyn, Earl G, Noble   +5 more
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Use of Hsf1−/− mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury

Toxicology and Applied Pharmacology, 2003
Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological ...
Wirth, D., Christians, E., Li, Xiang, Benjamin, I. J., Gustin, Pascal   +4 more
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Hsf1 in Her2-positive Breast Cancer

2011
Abstract : This study demonstrates that Hsf1 controls development of Her2-positive cancer both at the stage of initiation, via control of the oncogene-induced senescence, and progression, via regulation of tumor angiogenesis. It also dissects the mechanism of effects of Hsf1 on tumor angiogenesis, and demonstrates that Hsf1 regulates expression of the ...
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Linking HSF1 Activation to Translation

Science's STKE, 2006
Cells can survive heat stress by increasing the abundance of heat shock proteins (HSPs) and other cytoprotective proteins to prevent toxicity from excess improperly folded proteins. In addition, heat shock inhibits translation and disrupts the cytoskeleton.
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