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The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment
2020Tumors are stressful environments. As tumors evolve from single mutated cancer cells into invasive malignancies they must overcome various constraints and barriers imposed by a hostile microenvironment. To achieve this, cancer cells recruit and rewire cells in their microenvironment to become pro-tumorigenic.
Grunberg, Nil +2 more
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Inhibiting the transcription factor HSF1 as an anticancer strategy
Expert Opinion on Therapeutic Targets, 2009In mammals, the cytoprotective heat-shock response is regulated primarily by heat shock factor 1 (HSF1). Unfortunately, the effects of HSF1 also support the ability of cancer cells to accommodate imbalances in signaling and alterations in DNA, protein and energy metabolism associated with oncogenesis. The malignant lifestyle confers dependence on this '
Luke, Whitesell, Susan, Lindquist
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Role of HSF1 in Infectious Disease
2009The single heat shock transcription factor (HSF) in lower Metazoans and the heat-activated HSF family member in higher vertebrates, HSF1, not only play a central role in regulating the expression of heat shock protein (HSP) genes in response to stress, but may also play an important role in regulating the host immune response to infection.
Ishwar S. Singh +3 more
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Transcriptional regulation of small HSP—HSF1 and beyond
The International Journal of Biochemistry & Cell Biology, 2012The members of the small heat shock protein (sHSP) family are molecular chaperones that play major roles in development, stress responses, and diseases, and have been envisioned as targets for therapy, particularly in cancer. The molecular mechanisms that regulate their transcription, in normal, stress, or pathological conditions, are characterized by ...
de Thonel, Aurélie +2 more
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[Human HSF1 mutants and their applications].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2009Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional
Yun-Hong, Huang +2 more
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2007
Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
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Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
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Emerging roles of HSF1 in cancer: Cellular and molecular episodes
Biochimica Et Biophysica Acta: Reviews on Cancer, 2020Pengxiu Cao, Yumei Fan, Ke Tan
exaly
HSF1 activation and the control of apoptosis in chemoresistant cancers.
2007HSF1 ACTIVATION AND THE CONTROL OF APOPTOSIS IN CHEMORESISTANT CANCERS G. Belardo, A. Rossi, S. Ciafre', A. Ciucci, P. Gianferretti, S. Roberts and M.G. Santoro Department of Biology, University of Rome Tor Vergata and Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy; Department of Chemistry, University of Manchester, Manchester, UK ...
Belardo G +5 more
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