Results 181 to 190 of about 13,678 (223)
HSF1 as a Cancer Biomarker and Therapeutic Target [PDF]
Current Cancer Drug Targets, 2019 Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat shock response. In this classical role, HSF1 is activated following cellular stresses such as heat shock that ultimately lead to HSF1-mediated expression of heat shock ...
Richard L Carpenter, Yesim Gokmen-Polar
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HSF1: Guardian of Proteostasis in Cancer [PDF]
Trends in Cell Biology, 2016 Proteomic instability is causally related to human diseases. In guarding proteome stability, the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role. Contrasting with its beneficial role of enhancing cell survival, recent
Chengkai Dai
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AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
FEBS Journal, 2022 The heat stress response activates the transcription factor heat shock factor 1 (HSF1), which subsequently upregulates heat shock proteins to maintain the integrity of the proteome.
Haimanti Ray, , Natasha Hockaden
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Multifaceted roles of HSF1 in cancer
Tumor Biology, 2015 Heat shock transcription factor 1 (HSF1) is the master regulator of the heat shock response. Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and could serve as an independent diagnostic or prognostic biomarker. In this review, we will provide an overview of the multifaceted
Yuhua Zhao, Zhao Yuhua
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HSF1, Aging, and Neurodegeneration
2022Heat shock factor 1 (HSF1) is a master transcription regulator that mediates the induction of heat shock protein chaperones for quality control (QC) of the proteome and maintenance of proteostasis as a protective mechanism in response to stress.
Alice Y, Liu +4 more
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Rethinking HSF1 in Stress, Development, and Organismal Health [PDF]
Trends in Cell Biology, 2017 The heat shock response (HSR) was originally discovered as a transcriptional response to elevated temperature shock and led to the identification of heat shock proteins and heat shock factor 1 (HSF1). Since then HSF1 has been shown to be important for combating other forms of environmental perturbations as well as genetic variations that cause ...
Jian Li +2 more
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HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression
Cancer Research, 2008Abstract Previously, heat shock factor 1 (HSF1) had been reported to induce genomic instability and aneuploidy by interaction with Cdc20. Here, we have further examined the functions of HSF1 in the regulation of mitosis. A null mutant or knockdown of HSF1 caused defective mitotic progression. By monitoring chromosomes in living cells,
Yoon-Jin, Lee +6 more
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Science, 2013
Ribosome activity is linked to the activity of a transcription factor in cancer cells. [Also see Research Article by Santagata et al. ]
Valentina Gandin, Ivan Topisirovic
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Ribosome activity is linked to the activity of a transcription factor in cancer cells. [Also see Research Article by Santagata et al. ]
Valentina Gandin, Ivan Topisirovic
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Maternal effect of Hsf1 on reproductive success
Nature, 2000A protein known as heat-shock factor-1 (HSF1) is a major transactivator of stress-inducible genes in response to environmental changes, but it is also implicated in extra-embryonic development and female fertility in mice1,2. Here we show that mouse embryos whose mothers lack this protein are unable to develop properly beyond the zygotic stage ...
E, Christians +3 more
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