Results 181 to 190 of about 13,686 (217)
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HSF1, Aging, and Neurodegeneration
2022Heat shock factor 1 (HSF1) is a master transcription regulator that mediates the induction of heat shock protein chaperones for quality control (QC) of the proteome and maintenance of proteostasis as a protective mechanism in response to stress.
Alice Y, Liu +4 more
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Rethinking HSF1 in Stress, Development, and Organismal Health [PDF]
Trends in Cell Biology, 2017 The heat shock response (HSR) was originally discovered as a transcriptional response to elevated temperature shock and led to the identification of heat shock proteins and heat shock factor 1 (HSF1). Since then HSF1 has been shown to be important for combating other forms of environmental perturbations as well as genetic variations that cause ...
Jian Li +2 more
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HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression
Cancer Research, 2008Abstract Previously, heat shock factor 1 (HSF1) had been reported to induce genomic instability and aneuploidy by interaction with Cdc20. Here, we have further examined the functions of HSF1 in the regulation of mitosis. A null mutant or knockdown of HSF1 caused defective mitotic progression. By monitoring chromosomes in living cells,
Yoon-Jin, Lee +6 more
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Science, 2013
Ribosome activity is linked to the activity of a transcription factor in cancer cells. [Also see Research Article by Santagata et al. ]
Valentina Gandin, Ivan Topisirovic
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Ribosome activity is linked to the activity of a transcription factor in cancer cells. [Also see Research Article by Santagata et al. ]
Valentina Gandin, Ivan Topisirovic
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Regulation of HSF1 protein stabilization: An updated review
European Journal of Pharmacology, 2018Heat shock factor 1 (HSF1) is a transcriptional factor that determines the efficiency of heat shock responses (HSRs) in the cell. Given its function has been extensively studied in recent years, HSF1 is considered a potential target for the treatment of disorders associated with protein aggregation.
Chao Huang
exaly +3 more sources
Maternal effect of Hsf1 on reproductive success
Nature, 2000A protein known as heat-shock factor-1 (HSF1) is a major transactivator of stress-inducible genes in response to environmental changes, but it is also implicated in extra-embryonic development and female fertility in mice1,2. Here we show that mouse embryos whose mothers lack this protein are unable to develop properly beyond the zygotic stage ...
E, Christians +3 more
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Modulation of Hsf1 activity by novobiocin and geldanamycin
Biochemistry and Cell Biology, 2009Since Hsp90 is a known modulator of HSF1 activity, we examined the effects of two pharmacological inhibitors of Hsp90, novobiocin and geldanamycin, on HSF1 DNA-binding activity in the Xenopus oocyte model system. Novobiocin exhibits antiproliferative activity in culture cells and interacts with a C-terminal ATP-binding pocket on Hsp90, inhibiting ...
Renaud, Conde +4 more
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HSF1 and Its Role in Huntington’s Disease Pathology
2022Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR) in mammalian cells and is a critical element in maintaining protein homeostasis. HSF1 functions at the center of many physiological processes like embryogenesis, metabolism, immune response, aging, cancer, and neurodegeneration.
Hyuck, Kim, Rocio, Gomez-Pastor
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Regulation of Hsf1 and the Heat Shock Response
2020The heat shock response (HSR) is characterized by the induction of molecular chaperones following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of genes controlled by the transcription factor Hsf1. The HSR is induced by defects in co-translational protein folding, ribosome biogenesis, organellar targeting of nascent ...
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Toxicology and Applied Pharmacology, 2003
Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological ...
Wirth, D. +4 more
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Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological ...
Wirth, D. +4 more
openaire +2 more sources