Results 21 to 30 of about 12,403 (212)
In silico analysis of the structural and functional consequences of polymorphic amino acid substitutions in the cattle hsf1 protein [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Heat stress causes a decrease in the productivity of livestock by negatively aff ecting some important economic features such as fertility, growth and milk production.
Sertaç ATALAY
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION [PDF]
Human Molecular Genetics, 2017 Cellular protein homeostasis is achieved by a delicate network of molecular chaperones and various proteolytic processes such as ubiquitin-proteasome system (UPS) to avoid a build-up of misfolded protein aggregates. The latter is a common denominator of neurodegeneration.
Eunhee Kim, Eunhee Kim
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HSF1: Guardian of Proteostasis in Cancer [PDF]
Trends in Cell Biology, 2016 Proteomic instability is causally related to human diseases. In guarding proteome stability, the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role. Contrasting with its beneficial role of enhancing cell survival, recent findings have revealed a compelling pro-oncogenic role for HSF1. However, the mechanisms underlying
Dai, Chengkai, Sampson, Stephen B
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Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]
PLoS ONE, 2010 BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks +4 more
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Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the effect of FBXW7 on the expression and localization of HSF1 in colorectal cancer cells. Methods The expression levels of HSF1 and pHSF1Ser326 protein in FBXW7 deletion (KO) and wild-type (WT) FBXW7-expressing counterpart ...
SUN Ao, JIAO Han, FU Jiejun
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Cell Division, 2021 Background Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) and allow HSP expression during ...
Hsiao-Hui Kuo +3 more
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The HSF1-CPT1a Pathway Is Differentially Regulated in NAFLD Progression
Cells, 2022 Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD).
Wiebke Breternitz +10 more
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Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. [PDF]
PLoS ONE, 2008 BACKGROUND: Induction of the heat shock response (HSR) and increased expression of the heat shock proteins (HSPs) provide mechanisms to ensure proper protein folding, trafficking, and disposition.
Jingxian Yang +3 more
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Protein kinase A regulates molecular chaperone transcription and protein aggregation. [PDF]
PLoS ONE, 2011 Heat shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essential for deterrence of protein-folding disorders, particularly in neuronal cells.
Yue Zhang +3 more
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HSF1 Down-regulates XAF1 through Transcriptional Regulation [PDF]
Journal of Biological Chemistry, 2006 Studies have indicated the role of HSF1 (heat-shock transcription factor 1) in repressing the transcription of some nonheat shock genes. XAF1 (XIAP-associated factor 1) was an inhibitor of apoptosis-interacting protein with the effect of antagonizing the cytoprotective role of XIAP.
Lin, MCM +11 more
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