Results 31 to 40 of about 12,403 (212)
Protein kinase A binds and activates heat shock factor 1. [PDF]
PLoS ONE, 2010 Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli.
Ayesha Murshid +5 more
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RSK2 represses HSF1 activation during heat shock [PDF]
Cell Stress & Chaperones, 2000 Heat shock transcription factor 1(HSF1) activation is a multistep process. The conversion of a latent cytoplasmic form to a nuclear, DNA binding state appears to be activated by nonsteroidal anti-inflammatory drugs. In previous studies, we showed that HSF 1 is phosphorylated by the protein kinase RSK2 in vitro and that this effect is inhibited by ...
X, Wang +5 more
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Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
eLife, 2016 Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in
Xu Zheng +6 more
doaj +1 more source
iScience, 2022 Summary: Endometriosis is a common chronic condition characterized by abnormal growth of the endometrium outside the uterus. Heat shock transcription factor 1 (HSF1) is a significant regulator of the proteotoxic stress response and plays an essential ...
Xi Ling +9 more
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Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q
Human Genomics, 2017 Background HSF1 (heat shock factor 1) is a transcription factor that is found to facilitate malignant cancer development and proliferation. In cancer cells, HSF1 mediates a set of genes distinct from heat shock that contributes to malignancy. This set of
Christopher Q. Zhang +3 more
doaj +1 more source
Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. [PDF]
PLoS ONE, 2011 Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein
Liliana Batista-Nascimento +4 more
doaj +1 more source
HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways [PDF]
Cancers, 2019 Heat shock factor 1 (HSF1) is an essential transcription factor in cellular adaptation to various stresses such as heat, proteotoxic stress, metabolic stress, reactive oxygen species, and heavy metals. HSF1 promotes cancer development and progression, and increased HSF1 levels are frequently observed in multiple types of cancers.
Kang, Hyeji +7 more
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Scientific Reports, 2018 Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program.
Toshiki Kijima +12 more
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HSF1, A Versatile Factor in Tumorogenesis [PDF]
Current Molecular Medicine, 2012 HSF1 is an essential factor in the acute response to proteotoxic stress, in which it causes rapid transcription of heat shock protein (HSP) genes in order to permit survival of cells and restoration of global protein quality. In addition to this property however, HSF1 is chronically activated or overexpressed in a wide range of cancers and is essential
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Repression motif in HSF1 regulated by phosphorylation
Cellular Signalling, 2023 The heat shock factor 1 (HSF1) is a transcription factor that itself is a sensor for stress and integrates various intrinsic or environmental stress sensing pathways. Thus HSF1 orchestrates the heat shock response (HSR) by translating these pathways into a distinct transcriptional program that aids the cells to cope with and adapt to proteotoxic stress.
Stefan, Gabriel +2 more
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